Cargando…

Efficient Difluoromethylation of sp(3) Carbon Nucleophiles by Bromodifluoromethylation Reagents with Organic Bases

Detalles Bibliográficos
Autores principales:	Liu, Guokai, Wang, Xin, Lu, Xu, Xu, Xiu-Hua, Tokunaga, Etsuko, Shibata, Norio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2012
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922594/ https://www.ncbi.nlm.nih.gov/pubmed/24551513 http://dx.doi.org/10.1002/open.201200033

Ejemplares similares

Reagent-Controlled Highly Stereoselective Difluoromethylation: Efficient Access to Chiral α-Difluoromethylamines from Ketimines
por: Liu, Qinghe, et al.
Publicado: (2022)

A simple method for the synthesis of N-difluoromethylated pyridines and 4-pyridones/quinolones by using BrCF(2)COOEt as the difluoromethylation reagent
por: Gandioso, Albert, et al.
Publicado: (2020)

Reactions of Polyfluorobenzenes With Nucleophilic Reagents
por: Wall, Leo A., et al.
Publicado: (1963)

Renewable Reagent for Nucleophilic Fluorination
por: Alič, Blaž, et al.
Publicado: (2022)

Direct nucleophilic trifluoromethylation of carbonyl compounds by potent greenhouse gas, fluoroform: Improving the reactivity of anionoid trifluoromethyl species in glymes
por: Saito, Takuya, et al.
Publicado: (2018)

C–H Electrophilic (phenylsulfonyl)difluoromethylation of (hetero)arenes with a newly designed reagent
por: Nobile, Enzo, et al.
Publicado: (2021)

Enantioselective nucleophilic difluoromethylation of aromatic aldehydes with Me(3)SiCF(2)SO(2)Ph and PhSO(2)CF(2)H reagents catalyzed by chiral quaternary ammonium salts
por: Ni, Chuanfa, et al.
Publicado: (2008)

Cation versus Radical: Studies on the C/O Regioselectivity in Electrophilic Tri-, Di- and Monofluoromethylations of β-Ketoesters
por: Yang, Yu-Dong, et al.
Publicado: (2012)

Direct C–H difluoromethylation of heterocycles via organic photoredox catalysis
por: Zhang, Wei, et al.
Publicado: (2020)

Copper-catalyzed selective C5-H bromination and difluoromethylation of 8-aminoquinoline amides using ethyl bromodifluoroacetate as the bifunctional reagent
por: Shao, Changdong, et al.
Publicado: (2023)

Nucleophilic substitution reactions of monofunctional nucleophilic reagents with cyclotriphosphazenes containing 2,2-dioxybiphenyl units
por: TANRIVERDİ EÇİK, Esra, et al.
Publicado: (2020)

Facile Entry to Pharmaceutically Important 3-Difluoromethyl-Quinoxalin-2-Ones Enabled by Visible-Light-Driven Difluoromethylation of Quinoxalin-2-Ones
por: Fu, Kai-Zhong, et al.
Publicado: (2022)

Tandem addition of nucleophilic and electrophilic reagents to vinyl phosphinates: the stereoselective formation of organophosphorus compounds with congested tertiary carbons
por: Lin, Zhu, et al.
Publicado: (2023)

Copper-Promoted Cross-Coupling Reactions for the Synthesis of Aryl(difluoromethyl)phosphonates Using Trimethylsilyl(difluoromethyl)phosphonate
por: Komoda, Kazuki, et al.
Publicado: (2018)

Difluoromethylation of (hetero)aryl chlorides with chlorodifluoromethane catalyzed by nickel
por: Xu, Chang, et al.
Publicado: (2018)

Unusual Nucleophilic Addition of Grignard Reagents in the Synthesis of 4-Amino-pyrimidines
por: Tinson, Ryan A. J., et al.
Publicado: (2018)

Synthesis of a Hominal Bis(difluoromethyl) Fragment
por: Ivasyshyn, Viktor, et al.
Publicado: (2019)

Synthesis and Antibacterial Activity of Difluoromethyl Cinnamoyl Amides
por: Martínez, Mario David, et al.
Publicado: (2020)

Recent discoveries on the structure of iodine(iii) reagents and their use in cross-nucleophile coupling
por: Bauer, Adriano, et al.
Publicado: (2021)

1,3-Dibromo-1,1-difluoro-2-propanone as a Useful Synthon for a Chemoselective Preparation of 4-Bromodifluoromethyl Thiazoles
por: Colella, Marco, et al.
Publicado: (2018)

Palladium-catalyzed difluoromethylation of heteroaryl chlorides, bromides and iodides
por: Lu, Changhui, et al.
Publicado: (2017)

Nucleophilic fluoroalkylation/cyclization route to fluorinated phthalides
por: Inaba, Masanori, et al.
Publicado: (2018)

Sterically Demanding Unsymmetrical Diaryl-λ(3)-iodanes for Electrophilic Pentafluorophenylation and an Approach to α-Pentafluorophenyl Carbonyl Compounds with an All-Carbon Stereocenter
por: Matsuzaki, Kohei, et al.
Publicado: (2014)

Corrigendum: Sterically Demanding Unsymmetrical Diaryl‐λ(3)‐iodanes for Electrophilic Pentafluorophenylation and an Approach to α‐Pentafluorophenyl Carbonyl Compounds with an All‐Carbon Stereocenter
por: Matsuzaki, Kohei, et al.
Publicado: (2016)

Synthesis of difluoromethylated allenes through trifunctionalization of 1,3-enynes
por: Taj Muhammad, Munira, et al.
Publicado: (2020)

Copper-catalyzed carbo-difluoromethylation of alkenes via radical relay
por: Cai, Aijie, et al.
Publicado: (2021)

Diastereoselective Additive Trifluoromethylation/Halogenation of Isoxazole Triflones: Synthesis of All-Carbon-Functionalized Trifluoromethyl Isoxazoline Triflones
por: Kawai, Hiroyuki, et al.
Publicado: (2014)

Mechanochemical synthesis of magnesium-based carbon nucleophiles in air and their use in organic synthesis
por: Takahashi, Rina, et al.
Publicado: (2021)

Quaternary stereocentres via catalytic enantioconvergent nucleophilic substitution reactions of tertiary alkyl halides by alkenylmetal reagents
por: Wang, Zhaobin, et al.
Publicado: (2021)

A convenient approach to difluoromethylated all-carbon quaternary centers via Ni(ii)-catalyzed enantioselective Michael addition
por: Yu, Xuan, et al.
Publicado: (2018)

Stereoinvertive Nucleophilic Substitution at Quaternary Carbon Stereocenters of Cyclopropyl Ketones and Ethers
por: Chen, Xu, et al.
Publicado: (2022)

Catalytic asymmetric nucleophilic fluorination using BF(3)·Et(2)O as fluorine source and activating reagent
por: Zhu, Weiwei, et al.
Publicado: (2021)

Novel synthesis of pseudopeptides bearing a difluoromethyl group by Ugi reaction and desulfanylation
por: Wu, Jingjing, et al.
Publicado: (2011)

Ruthenium(II)-enabled para-selective C–H difluoromethylation of anilides and their derivatives
por: Yuan, Chunchen, et al.
Publicado: (2018)

Photocatalytic Difluoromethylation Reactions of Aromatic Compounds and Aliphatic Multiple C–C Bonds
por: Barata-Vallejo, Sebastián, et al.
Publicado: (2019)

Electrooxidative dearomatization of biaryls: synthesis of tri- and difluoromethylated spiro[5.5]trienones
por: Zhang, Yan, et al.
Publicado: (2021)

Three-Dimensional Heterocycles: New Uracil-Based Structures Obtained by Nucleophilic Substitution at the sp(2) Carbon of Bromoisoxazoline
por: Memeo, Misal Giuseppe, et al.
Publicado: (2014)

Shelf-stable electrophilic trifluoromethylating reagents: A brief historical perspective
por: Shibata, Norio, et al.
Publicado: (2010)

Organocatalyzed Trifluoromethylation of Ketones and Sulfonyl Fluorides by Fluoroform under a Superbase System
por: Okusu, Satoshi, et al.
Publicado: (2015)

Regioselective 1,4-trifluoromethylation of α,β-unsaturated ketones via a S-(trifluoromethyl)diphenylsulfonium salts/copper system
por: Okusu, Satoshi, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_98qejq59bnha14fhumr2dnb7mr