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Exposure measurement error in PM(2.5) health effects studies: A pooled analysis of eight personal exposure validation studies
BACKGROUND: Exposure measurement error is a concern in long-term PM(2.5) health studies using ambient concentrations as exposures. We assessed error magnitude by estimating calibration coefficients as the association between personal PM(2.5) exposures from validation studies and typically available...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922798/ https://www.ncbi.nlm.nih.gov/pubmed/24410940 http://dx.doi.org/10.1186/1476-069X-13-2 |
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author | Kioumourtzoglou, Marianthi-Anna Spiegelman, Donna Szpiro, Adam A Sheppard, Lianne Kaufman, Joel D Yanosky, Jeff D Williams, Ronald Laden, Francine Hong, Biling Suh, Helen |
author_facet | Kioumourtzoglou, Marianthi-Anna Spiegelman, Donna Szpiro, Adam A Sheppard, Lianne Kaufman, Joel D Yanosky, Jeff D Williams, Ronald Laden, Francine Hong, Biling Suh, Helen |
author_sort | Kioumourtzoglou, Marianthi-Anna |
collection | PubMed |
description | BACKGROUND: Exposure measurement error is a concern in long-term PM(2.5) health studies using ambient concentrations as exposures. We assessed error magnitude by estimating calibration coefficients as the association between personal PM(2.5) exposures from validation studies and typically available surrogate exposures. METHODS: Daily personal and ambient PM(2.5), and when available sulfate, measurements were compiled from nine cities, over 2 to 12 days. True exposure was defined as personal exposure to PM(2.5) of ambient origin. Since PM(2.5) of ambient origin could only be determined for five cities, personal exposure to total PM(2.5) was also considered. Surrogate exposures were estimated as ambient PM(2.5) at the nearest monitor or predicted outside subjects’ homes. We estimated calibration coefficients by regressing true on surrogate exposures in random effects models. RESULTS: When monthly-averaged personal PM(2.5) of ambient origin was used as the true exposure, calibration coefficients equaled 0.31 (95% CI:0.14, 0.47) for nearest monitor and 0.54 (95% CI:0.42, 0.65) for outdoor home predictions. Between-city heterogeneity was not found for outdoor home PM(2.5) for either true exposure. Heterogeneity was significant for nearest monitor PM(2.5), for both true exposures, but not after adjusting for city-average motor vehicle number for total personal PM(2.5). CONCLUSIONS: Calibration coefficients were <1, consistent with previously reported chronic health risks using nearest monitor exposures being under-estimated when ambient concentrations are the exposure of interest. Calibration coefficients were closer to 1 for outdoor home predictions, likely reflecting less spatial error. Further research is needed to determine how our findings can be incorporated in future health studies. |
format | Online Article Text |
id | pubmed-3922798 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-39227982014-02-28 Exposure measurement error in PM(2.5) health effects studies: A pooled analysis of eight personal exposure validation studies Kioumourtzoglou, Marianthi-Anna Spiegelman, Donna Szpiro, Adam A Sheppard, Lianne Kaufman, Joel D Yanosky, Jeff D Williams, Ronald Laden, Francine Hong, Biling Suh, Helen Environ Health Research BACKGROUND: Exposure measurement error is a concern in long-term PM(2.5) health studies using ambient concentrations as exposures. We assessed error magnitude by estimating calibration coefficients as the association between personal PM(2.5) exposures from validation studies and typically available surrogate exposures. METHODS: Daily personal and ambient PM(2.5), and when available sulfate, measurements were compiled from nine cities, over 2 to 12 days. True exposure was defined as personal exposure to PM(2.5) of ambient origin. Since PM(2.5) of ambient origin could only be determined for five cities, personal exposure to total PM(2.5) was also considered. Surrogate exposures were estimated as ambient PM(2.5) at the nearest monitor or predicted outside subjects’ homes. We estimated calibration coefficients by regressing true on surrogate exposures in random effects models. RESULTS: When monthly-averaged personal PM(2.5) of ambient origin was used as the true exposure, calibration coefficients equaled 0.31 (95% CI:0.14, 0.47) for nearest monitor and 0.54 (95% CI:0.42, 0.65) for outdoor home predictions. Between-city heterogeneity was not found for outdoor home PM(2.5) for either true exposure. Heterogeneity was significant for nearest monitor PM(2.5), for both true exposures, but not after adjusting for city-average motor vehicle number for total personal PM(2.5). CONCLUSIONS: Calibration coefficients were <1, consistent with previously reported chronic health risks using nearest monitor exposures being under-estimated when ambient concentrations are the exposure of interest. Calibration coefficients were closer to 1 for outdoor home predictions, likely reflecting less spatial error. Further research is needed to determine how our findings can be incorporated in future health studies. BioMed Central 2014-01-13 /pmc/articles/PMC3922798/ /pubmed/24410940 http://dx.doi.org/10.1186/1476-069X-13-2 Text en Copyright © 2014 Kioumourtzoglou et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License(http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Kioumourtzoglou, Marianthi-Anna Spiegelman, Donna Szpiro, Adam A Sheppard, Lianne Kaufman, Joel D Yanosky, Jeff D Williams, Ronald Laden, Francine Hong, Biling Suh, Helen Exposure measurement error in PM(2.5) health effects studies: A pooled analysis of eight personal exposure validation studies |
title | Exposure measurement error in PM(2.5) health effects studies: A pooled analysis of eight personal exposure validation studies |
title_full | Exposure measurement error in PM(2.5) health effects studies: A pooled analysis of eight personal exposure validation studies |
title_fullStr | Exposure measurement error in PM(2.5) health effects studies: A pooled analysis of eight personal exposure validation studies |
title_full_unstemmed | Exposure measurement error in PM(2.5) health effects studies: A pooled analysis of eight personal exposure validation studies |
title_short | Exposure measurement error in PM(2.5) health effects studies: A pooled analysis of eight personal exposure validation studies |
title_sort | exposure measurement error in pm(2.5) health effects studies: a pooled analysis of eight personal exposure validation studies |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922798/ https://www.ncbi.nlm.nih.gov/pubmed/24410940 http://dx.doi.org/10.1186/1476-069X-13-2 |
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