Accumulation of prelamin A compromises NF-κB-regulated B-lymphopoiesis in a progeria mouse model

BACKGROUND: Alteration in the immune system is one of the most profound aspects of aging. Progressive changes in the number of B lymphocyte progenitors during aging have been reported but the underlying mechanisms are still elusive. A heterozygous G608G mutation in the LMNA gene leads to a deletion...

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Detalles Bibliográficos
Autores principales: Liu, Baohua, Zhou, Shuangcheng, Liu, Xinguang, Zhou, Keyuan, Zhang, Fengju, Zhou, Zhongjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922919/
https://www.ncbi.nlm.nih.gov/pubmed/24764515
http://dx.doi.org/10.1186/2046-2395-2-1

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