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Lifespan extension and delay of age-related functional decline caused by Rhodiola rosea depends on dietary macronutrient balance
BACKGROUND: This study was conducted to evaluate the effects of rhizome powder from the herb Rhodiola rosea, a traditional Western Ukraine medicinal adaptogen, on lifespan and age-related physiological functions of the fruit fly Drosophila melanogaster. RESULTS: Flies fed food supplemented with 5.0...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922952/ https://www.ncbi.nlm.nih.gov/pubmed/24472572 http://dx.doi.org/10.1186/2046-2395-2-5 |
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author | Gospodaryov, Dmytro V Yurkevych, Ihor S Jafari, Mahtab Lushchak, Volodymyr I Lushchak, Oleh V |
author_facet | Gospodaryov, Dmytro V Yurkevych, Ihor S Jafari, Mahtab Lushchak, Volodymyr I Lushchak, Oleh V |
author_sort | Gospodaryov, Dmytro V |
collection | PubMed |
description | BACKGROUND: This study was conducted to evaluate the effects of rhizome powder from the herb Rhodiola rosea, a traditional Western Ukraine medicinal adaptogen, on lifespan and age-related physiological functions of the fruit fly Drosophila melanogaster. RESULTS: Flies fed food supplemented with 5.0 mg/ml and 10.0 mg/ml of R. rosea rhizome powder had a 14% to 17% higher median lifespan, whereas at 30.0 mg/ml lifespan was decreased by 9% to 12%. The preparation did not decrease fly fecundity. The effect of R. rosea supplement on lifespan was dependent on diet composition. Lifespan extension by 15% to 21% was observed only for diets with protein-to-carbohydrate ratios less than 1. Lifespan extension was also dependent on total concentration of macronutrients. Thus, for the diet with 15% yeast and 15% sucrose there was no lifespan extension, while for the diet with protein-to-carbohydrate ratio 20:1 R. rosea decreased lifespan by about 10%. Flies fed Rhodiola preparation were physically more active, less sensitive to the redox-cycling compound menadione and had a longer time of heat coma onset compared with controls. Positive effects of Rhodiola rhizome on stress resistance and locomotor activity were highest at the ‘middle age’. CONCLUSIONS: The present data show that long-term food supplementation with R. rosea rhizome not only increases D. melanogaster lifespan, but also delays age-related decline of physical activity and increases stress resistance, what depends on protein-to-carbohydrate ratio of the diet. |
format | Online Article Text |
id | pubmed-3922952 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-39229522014-02-28 Lifespan extension and delay of age-related functional decline caused by Rhodiola rosea depends on dietary macronutrient balance Gospodaryov, Dmytro V Yurkevych, Ihor S Jafari, Mahtab Lushchak, Volodymyr I Lushchak, Oleh V Longev Healthspan Research BACKGROUND: This study was conducted to evaluate the effects of rhizome powder from the herb Rhodiola rosea, a traditional Western Ukraine medicinal adaptogen, on lifespan and age-related physiological functions of the fruit fly Drosophila melanogaster. RESULTS: Flies fed food supplemented with 5.0 mg/ml and 10.0 mg/ml of R. rosea rhizome powder had a 14% to 17% higher median lifespan, whereas at 30.0 mg/ml lifespan was decreased by 9% to 12%. The preparation did not decrease fly fecundity. The effect of R. rosea supplement on lifespan was dependent on diet composition. Lifespan extension by 15% to 21% was observed only for diets with protein-to-carbohydrate ratios less than 1. Lifespan extension was also dependent on total concentration of macronutrients. Thus, for the diet with 15% yeast and 15% sucrose there was no lifespan extension, while for the diet with protein-to-carbohydrate ratio 20:1 R. rosea decreased lifespan by about 10%. Flies fed Rhodiola preparation were physically more active, less sensitive to the redox-cycling compound menadione and had a longer time of heat coma onset compared with controls. Positive effects of Rhodiola rhizome on stress resistance and locomotor activity were highest at the ‘middle age’. CONCLUSIONS: The present data show that long-term food supplementation with R. rosea rhizome not only increases D. melanogaster lifespan, but also delays age-related decline of physical activity and increases stress resistance, what depends on protein-to-carbohydrate ratio of the diet. BioMed Central 2013-04-02 /pmc/articles/PMC3922952/ /pubmed/24472572 http://dx.doi.org/10.1186/2046-2395-2-5 Text en Copyright © 2013 Gospodaryov et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Gospodaryov, Dmytro V Yurkevych, Ihor S Jafari, Mahtab Lushchak, Volodymyr I Lushchak, Oleh V Lifespan extension and delay of age-related functional decline caused by Rhodiola rosea depends on dietary macronutrient balance |
title | Lifespan extension and delay of age-related functional decline caused by Rhodiola rosea depends on dietary macronutrient balance |
title_full | Lifespan extension and delay of age-related functional decline caused by Rhodiola rosea depends on dietary macronutrient balance |
title_fullStr | Lifespan extension and delay of age-related functional decline caused by Rhodiola rosea depends on dietary macronutrient balance |
title_full_unstemmed | Lifespan extension and delay of age-related functional decline caused by Rhodiola rosea depends on dietary macronutrient balance |
title_short | Lifespan extension and delay of age-related functional decline caused by Rhodiola rosea depends on dietary macronutrient balance |
title_sort | lifespan extension and delay of age-related functional decline caused by rhodiola rosea depends on dietary macronutrient balance |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922952/ https://www.ncbi.nlm.nih.gov/pubmed/24472572 http://dx.doi.org/10.1186/2046-2395-2-5 |
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