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Serum Immunoglobulin M Concentration Is Positively Related to Metabolic Syndrome in an Adult Population: Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIH) Cohort Study

Persistent low-grade systemic inflammation has been increasingly recognized as a common pathological process, and an important contributing factor to cardiovascular diseases and its risk factor, metabolic syndrome. Immunoglobulin M is reactive to multiple autoantigens and is inferred to be important...

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Autores principales: Song, Kun, Du, Huanmin, Zhang, Qing, Wang, Chongjin, Guo, Yinting, Wu, Hongmei, Liu, Li, Jia, Qiyu, Wang, Xing, Shi, Hongbin, Sun, Shaomei, Niu, Kaijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923043/
https://www.ncbi.nlm.nih.gov/pubmed/24533139
http://dx.doi.org/10.1371/journal.pone.0088701
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author Song, Kun
Du, Huanmin
Zhang, Qing
Wang, Chongjin
Guo, Yinting
Wu, Hongmei
Liu, Li
Jia, Qiyu
Wang, Xing
Shi, Hongbin
Sun, Shaomei
Niu, Kaijun
author_facet Song, Kun
Du, Huanmin
Zhang, Qing
Wang, Chongjin
Guo, Yinting
Wu, Hongmei
Liu, Li
Jia, Qiyu
Wang, Xing
Shi, Hongbin
Sun, Shaomei
Niu, Kaijun
author_sort Song, Kun
collection PubMed
description Persistent low-grade systemic inflammation has been increasingly recognized as a common pathological process, and an important contributing factor to cardiovascular diseases and its risk factor, metabolic syndrome. Immunoglobulin M is reactive to multiple autoantigens and is inferred to be important for autoimmunity, implying that immunoglobulin M may be a potential risk factor for metabolic syndrome. However, few epidemiological studies are available which are related to this potential link. Therefore, we designed a cross-sectional study of 9,379 subjects to evaluate the relationship between immunoglobulin M and metabolic syndrome in an adult population. Subjects who received health examinations were recruited from the Tianjin Medical University General Hospital-Health Management Center in Tianjin, China. Immunoglobulin M was determined with an immunonephelometric technique. Metabolic syndrome was defined according to the criteria of the American Heart Association scientific statements of 2009. Multiple logistic regression analysis was used to examine the relationships between the quartiles of immunoglobulin M and the prevalence of metabolic syndrome. After adjustment for covariates, the odds ratio of having metabolic syndrome in the fourth quartile compared with the first quartile of immunoglobulin M was 1.19 times for males (95% confidence interval, 1.002–1.41) and 1.39 times for females (95% confidence interval, 1.07–1.80). Immunoglobulin M levels also showed positive relationships with the ratio of elevated triglycerides and reduced high-density lipoprotein cholesterol in males. The study is the first to show that immunoglobulin M is independently related to metabolic syndrome and its individual components (elevated triglycerides and reduced high-density lipoprotein cholesterol) in males, whereas immunoglobulin M is independently related to metabolic syndrome in females but not to its individual components. Further studies are needed to explore the causality and the exact role of immunoglobulin M in metabolic syndrome.
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spelling pubmed-39230432014-02-14 Serum Immunoglobulin M Concentration Is Positively Related to Metabolic Syndrome in an Adult Population: Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIH) Cohort Study Song, Kun Du, Huanmin Zhang, Qing Wang, Chongjin Guo, Yinting Wu, Hongmei Liu, Li Jia, Qiyu Wang, Xing Shi, Hongbin Sun, Shaomei Niu, Kaijun PLoS One Research Article Persistent low-grade systemic inflammation has been increasingly recognized as a common pathological process, and an important contributing factor to cardiovascular diseases and its risk factor, metabolic syndrome. Immunoglobulin M is reactive to multiple autoantigens and is inferred to be important for autoimmunity, implying that immunoglobulin M may be a potential risk factor for metabolic syndrome. However, few epidemiological studies are available which are related to this potential link. Therefore, we designed a cross-sectional study of 9,379 subjects to evaluate the relationship between immunoglobulin M and metabolic syndrome in an adult population. Subjects who received health examinations were recruited from the Tianjin Medical University General Hospital-Health Management Center in Tianjin, China. Immunoglobulin M was determined with an immunonephelometric technique. Metabolic syndrome was defined according to the criteria of the American Heart Association scientific statements of 2009. Multiple logistic regression analysis was used to examine the relationships between the quartiles of immunoglobulin M and the prevalence of metabolic syndrome. After adjustment for covariates, the odds ratio of having metabolic syndrome in the fourth quartile compared with the first quartile of immunoglobulin M was 1.19 times for males (95% confidence interval, 1.002–1.41) and 1.39 times for females (95% confidence interval, 1.07–1.80). Immunoglobulin M levels also showed positive relationships with the ratio of elevated triglycerides and reduced high-density lipoprotein cholesterol in males. The study is the first to show that immunoglobulin M is independently related to metabolic syndrome and its individual components (elevated triglycerides and reduced high-density lipoprotein cholesterol) in males, whereas immunoglobulin M is independently related to metabolic syndrome in females but not to its individual components. Further studies are needed to explore the causality and the exact role of immunoglobulin M in metabolic syndrome. Public Library of Science 2014-02-12 /pmc/articles/PMC3923043/ /pubmed/24533139 http://dx.doi.org/10.1371/journal.pone.0088701 Text en © 2014 Song et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Song, Kun
Du, Huanmin
Zhang, Qing
Wang, Chongjin
Guo, Yinting
Wu, Hongmei
Liu, Li
Jia, Qiyu
Wang, Xing
Shi, Hongbin
Sun, Shaomei
Niu, Kaijun
Serum Immunoglobulin M Concentration Is Positively Related to Metabolic Syndrome in an Adult Population: Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIH) Cohort Study
title Serum Immunoglobulin M Concentration Is Positively Related to Metabolic Syndrome in an Adult Population: Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIH) Cohort Study
title_full Serum Immunoglobulin M Concentration Is Positively Related to Metabolic Syndrome in an Adult Population: Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIH) Cohort Study
title_fullStr Serum Immunoglobulin M Concentration Is Positively Related to Metabolic Syndrome in an Adult Population: Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIH) Cohort Study
title_full_unstemmed Serum Immunoglobulin M Concentration Is Positively Related to Metabolic Syndrome in an Adult Population: Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIH) Cohort Study
title_short Serum Immunoglobulin M Concentration Is Positively Related to Metabolic Syndrome in an Adult Population: Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIH) Cohort Study
title_sort serum immunoglobulin m concentration is positively related to metabolic syndrome in an adult population: tianjin chronic low-grade systemic inflammation and health (tclsih) cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923043/
https://www.ncbi.nlm.nih.gov/pubmed/24533139
http://dx.doi.org/10.1371/journal.pone.0088701
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