Cargando…

Glial Cell Ceruloplasmin and Hepcidin Differentially Regulate Iron Efflux from Brain Microvascular Endothelial Cells

We have used an in vitro model system to probe the iron transport pathway across the brain microvascular endothelial cells (BMVEC) of the blood-brain barrier (BBB). This model consists of human BMVEC (hBMVEC) and C6 glioma cells (as an astrocytic cell line) grown in a transwell, a cell culture syste...

Descripción completa

Detalles Bibliográficos
Autores principales:	McCarthy, Ryan C., Kosman, Daniel J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923066/ https://www.ncbi.nlm.nih.gov/pubmed/24533165 http://dx.doi.org/10.1371/journal.pone.0089003

Ejemplares similares

Activation of C6 glioblastoma cell ceruloplasmin expression by neighboring human brain endothelia-derived interleukins in an in vitro blood–brain barrier model system
por: McCarthy, Ryan C, et al.
Publicado: (2014)

Mechanisms and regulation of iron trafficking across the capillary endothelial cells of the blood-brain barrier
por: McCarthy, Ryan C., et al.
Publicado: (2015)

The iron chelator, PBT434, modulates transcellular iron trafficking in brain microvascular endothelial cells
por: Bailey, Danielle K., et al.
Publicado: (2021)

Astrocyte-derived hepcidin controls iron traffic at the blood-brain-barrier via regulating ferroportin 1 of microvascular endothelial cells
por: You, Linhao, et al.
Publicado: (2022)

Ceruloplasmin and hephaestin jointly protect the exocrine pancreas against oxidative damage by facilitating iron efflux
por: Chen, Min, et al.
Publicado: (2018)

Iron Deficiency in Inflammatory Bowel Disease Is Associated With Low Levels of Vitamin D Modulating Serum Hepcidin and Intestinal Ceruloplasmin Expression
por: Stallhofer, Johannes, et al.
Publicado: (2022)

Hepcidin Is Involved in Iron Regulation in the Ischemic Brain
por: Ding, Hui, et al.
Publicado: (2011)

Frataxin-deficient human brain microvascular endothelial cells lose polymerized actin and are paracellularly permeable –implications for blood-brain barrier integrity in Friedreich’s Ataxia
por: Smith, Frances M., et al.
Publicado: (2023)

Upregulation of brain hepcidin in prion diseases: Short title: Hepcidin and brain iron accumulation
por: Chaudhary, Suman, et al.
Publicado: (2021)

Ceruloplasmin and Iron Proteins in the Serum of Patients with Alzheimer's Disease
por: Torsdottir, Gudlaug, et al.
Publicado: (2011)

Hephaestin and ceruloplasmin facilitate iron metabolism in the mouse kidney
por: Jiang, Bo, et al.
Publicado: (2016)

Hepcidin: regulation of the master iron regulator
por: Rishi, Gautam, et al.
Publicado: (2015)

Ceruloplasmin deletion in myelinating glial cells induces myelin disruption and oxidative stress in the central and peripheral nervous systems
por: Santiago González, D.A., et al.
Publicado: (2021)

Hepcidin, an emerging and important player in brain iron homeostasis
por: Vela, Driton
Publicado: (2018)

The Dual Role of Hepcidin in Brain Iron Load and Inflammation
por: Vela, Driton
Publicado: (2018)

Ceruloplasmin: Macromolecular Assemblies with Iron-Containing Acute Phase Proteins
por: Samygina, Valeriya R., et al.
Publicado: (2013)

Ceruloplasmin activity and iron chelation treatment of patients with Parkinson’s disease
por: Grolez, Guillaume, et al.
Publicado: (2015)

Iron, anemia and hepcidin in malaria
por: Spottiswoode, Natasha, et al.
Publicado: (2014)

Iron, hepcidin, and the metal connection
por: Loréal, Olivier, et al.
Publicado: (2014)

Hepcidin and Iron in Health and Disease
por: Nemeth, Elizabeta, et al.
Publicado: (2023)

Calcium and the Ca-ATPase SPCA1 modulate plasma membrane abundance of ZIP8 and ZIP14 to regulate Mn(II) uptake in brain microvascular endothelial cells
por: Steimle, Brittany L., et al.
Publicado: (2022)

Erythroferrone: An Erythroid Regulator of Hepcidin and Iron Metabolism
por: Coffey, Richard, et al.
Publicado: (2018)

An essential cell-autonomous role for hepcidin in cardiac iron homeostasis
por: Lakhal-Littleton, Samira, et al.
Publicado: (2016)

Hepcidin and iron-mediated resistance to malaria
por: Prentice, Andrew M
Publicado: (2011)

Hepcidin and the iron enigma in HCV infection
por: Georgopoulou, Urania, et al.
Publicado: (2014)

Hepcidin and Iron Homeostasis during Pregnancy
por: Koenig, Mary Dawn, et al.
Publicado: (2014)

Hepcidin and Its Role in Iron Homeostasis
por: Kwapisz, Justyna, et al.
Publicado: (2009)

Iron metabolism and iron disorders revisited in the hepcidin era
por: Camaschella, Clara, et al.
Publicado: (2020)

Iron Together with Lipid Downregulates Protein Levels of Ceruloplasmin in Macrophages Associated with Rapid Foam Cell Formation
por: Wang, Qi, et al.
Publicado: (2016)

Iron transport across the human placenta is regulated by hepcidin
por: McDonald, E. A., et al.
Publicado: (2022)

The Role of Hepcidin in Regulating Iron Homeostasis in Selected Diseases
por: Radosz, Aleksandra, et al.
Publicado: (2019)

Ceruloplasmin and iron in Alzheimer’s disease and Parkinson’s disease: a synopsis of recent studies
por: Kristinsson, Jakob, et al.
Publicado: (2012)

Assessing whether serum ceruloplasmin promotes non-alcoholic steatohepatitis via regulating iron metabolism
por: Xia, Ziqiang, et al.
Publicado: (2023)

Isolation of Primary Murine Brain Microvascular Endothelial Cells
por: Ruck, Tobias, et al.
Publicado: (2014)

Effects of Fullerenols on Mouse Brain Microvascular Endothelial Cells
por: Schuhmann, Michael K., et al.
Publicado: (2017)

Serum hepcidin levels and iron parameters in children with iron deficiency
por: Choi, Hyoung Soo, et al.
Publicado: (2012)

Hepcidin-mediated Iron Regulation in P19 Cells is Detectable by Magnetic Resonance Imaging
por: Alizadeh, Kobra, et al.
Publicado: (2020)

Urinary Hepcidin Levels in Iron-Deficient and Iron-Supplemented Piglets Correlate with Hepcidin Hepatic mRNA and Serum Levels and with Body Iron Status
por: Staroń, Robert, et al.
Publicado: (2015)

The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer’s disease
por: Raha, Animesh Alexander, et al.
Publicado: (2013)

Aging is associated with increased brain iron through cortex-derived hepcidin expression
por: Sato, Tatsuya, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_t0oqerm0gul1o1l84t9b9pu0t4