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Proline-Hydroxylated Hypoxia-Inducible Factor 1α (HIF-1α) Upregulation in Human Tumours

The stabilisation of HIF-α is central to the transcriptional response of animals to hypoxia, regulating the expression of hundreds of genes including those involved in angiogenesis, metabolism and metastasis. HIF-α is degraded under normoxic conditions by proline hydroxylation, which allows for reco...

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Detalles Bibliográficos
Autores principales:	Snell, Cameron E., Turley, Helen, McIntyre, Alan, Li, Demin, Masiero, Massimo, Schofield, Christopher J., Gatter, Kevin C., Harris, Adrian L., Pezzella, Francesco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923075/ https://www.ncbi.nlm.nih.gov/pubmed/24563687 http://dx.doi.org/10.1371/journal.pone.0088955

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