Self-Antigen Presentation by Dendritic Cells in Autoimmunity

The operation of both central and peripheral tolerance ensures the prevention of autoimmune diseases. The maintenance of peripheral tolerance requires self-antigen presentation by professional antigen presenting cells (APCs). Dendritic cells (DCs) are considered as major APCs involved in this proces...

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Detalles Bibliográficos
Autores principales: Hopp, Ann-Katrin, Rupp, Anne, Lukacs-Kornek, Veronika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923158/
https://www.ncbi.nlm.nih.gov/pubmed/24592266
http://dx.doi.org/10.3389/fimmu.2014.00055
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author Hopp, Ann-Katrin
Rupp, Anne
Lukacs-Kornek, Veronika
author_facet Hopp, Ann-Katrin
Rupp, Anne
Lukacs-Kornek, Veronika
author_sort Hopp, Ann-Katrin
collection PubMed
description The operation of both central and peripheral tolerance ensures the prevention of autoimmune diseases. The maintenance of peripheral tolerance requires self-antigen presentation by professional antigen presenting cells (APCs). Dendritic cells (DCs) are considered as major APCs involved in this process. The current review discusses the role of DCs in autoimmune diseases, the various factors involved in the induction and maintenance of tolerogenic DC phenotype, and pinpoints their therapeutic capacity as well as potential novel targets for future clinical studies.
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spelling pubmed-39231582014-03-03 Self-Antigen Presentation by Dendritic Cells in Autoimmunity Hopp, Ann-Katrin Rupp, Anne Lukacs-Kornek, Veronika Front Immunol Immunology The operation of both central and peripheral tolerance ensures the prevention of autoimmune diseases. The maintenance of peripheral tolerance requires self-antigen presentation by professional antigen presenting cells (APCs). Dendritic cells (DCs) are considered as major APCs involved in this process. The current review discusses the role of DCs in autoimmune diseases, the various factors involved in the induction and maintenance of tolerogenic DC phenotype, and pinpoints their therapeutic capacity as well as potential novel targets for future clinical studies. Frontiers Media S.A. 2014-02-13 /pmc/articles/PMC3923158/ /pubmed/24592266 http://dx.doi.org/10.3389/fimmu.2014.00055 Text en Copyright © 2014 Hopp, Rupp and Lukacs-Kornek. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Hopp, Ann-Katrin
Rupp, Anne
Lukacs-Kornek, Veronika
Self-Antigen Presentation by Dendritic Cells in Autoimmunity
title Self-Antigen Presentation by Dendritic Cells in Autoimmunity
title_full Self-Antigen Presentation by Dendritic Cells in Autoimmunity
title_fullStr Self-Antigen Presentation by Dendritic Cells in Autoimmunity
title_full_unstemmed Self-Antigen Presentation by Dendritic Cells in Autoimmunity
title_short Self-Antigen Presentation by Dendritic Cells in Autoimmunity
title_sort self-antigen presentation by dendritic cells in autoimmunity
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923158/
https://www.ncbi.nlm.nih.gov/pubmed/24592266
http://dx.doi.org/10.3389/fimmu.2014.00055
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AT lukacskornekveronika selfantigenpresentationbydendriticcellsinautoimmunity

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