The TIF1β-HP1 System Maintains Transcriptional Integrity of Hematopoietic Stem Cells

TIF1β is a transcriptional corepressor that recruits repressive chromatin modifiers to target genes. Its biological function and physiological targets in somatic stem cells remain largely unknown. Here, we show that TIF1β is essential for the maintenance of hematopoietic stem cells (HSCs). Deletion...

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Detalles Bibliográficos
Autores principales: Miyagi, Satoru, Koide, Shuhei, Saraya, Atsunori, Wendt, George R., Oshima, Motohiko, Konuma, Takaaki, Yamazaki, Satoshi, Mochizuki-Kashio, Makiko, Nakajima-Takagi, Yaeko, Wang, Changshan, Chiba, Tetsuhiro, Kitabayashi, Issay, Nakauchi, Hiromitsu, Iwama, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923190/
https://www.ncbi.nlm.nih.gov/pubmed/24527388
http://dx.doi.org/10.1016/j.stemcr.2013.12.008

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