The use of 2D fingerprint methods to support the assessment of structural similarity in orphan drug legislation

BACKGROUND: In the European Union, medicines are authorised for some rare disease only if they are judged to be dissimilar to authorised orphan drugs for that disease. This paper describes the use of 2D fingerprints to show the extent of the relationship between computed levels of structural similar...

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Detalles Bibliográficos
Autores principales: Franco, Pedro, Porta, Nuria, Holliday, John D, Willett, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923256/
https://www.ncbi.nlm.nih.gov/pubmed/24485002
http://dx.doi.org/10.1186/1758-2946-6-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923256/
https://www.ncbi.nlm.nih.gov/pubmed/24485002
http://dx.doi.org/10.1186/1758-2946-6-5

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