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The use of 2D fingerprint methods to support the assessment of structural similarity in orphan drug legislation
BACKGROUND: In the European Union, medicines are authorised for some rare disease only if they are judged to be dissimilar to authorised orphan drugs for that disease. This paper describes the use of 2D fingerprints to show the extent of the relationship between computed levels of structural similar...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923256/ https://www.ncbi.nlm.nih.gov/pubmed/24485002 http://dx.doi.org/10.1186/1758-2946-6-5 |