Vpx rescue of HIV-1 from the antiviral state in mature dendritic cells is independent of the intracellular deoxynucleotide concentration

BACKGROUND: SIV(MAC)/HIV-2 Vpx recruits the CUL4A-DCAF1 E3 ubiquitin ligase complex to degrade the deoxynucleotide hydrolase SAMHD1. This increases the concentration of deoxynucleotides available for reverse transcription in myeloid cells and resting T cells. Accordingly, transduction of these cells...

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Detalles Bibliográficos
Autores principales: Reinhard, Christian, Bottinelli, Dario, Kim, Baek, Luban, Jeremy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923257/
https://www.ncbi.nlm.nih.gov/pubmed/24485168
http://dx.doi.org/10.1186/1742-4690-11-12

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923257/
https://www.ncbi.nlm.nih.gov/pubmed/24485168
http://dx.doi.org/10.1186/1742-4690-11-12

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