Cargando…

Vpx rescue of HIV-1 from the antiviral state in mature dendritic cells is independent of the intracellular deoxynucleotide concentration

BACKGROUND: SIV(MAC)/HIV-2 Vpx recruits the CUL4A-DCAF1 E3 ubiquitin ligase complex to degrade the deoxynucleotide hydrolase SAMHD1. This increases the concentration of deoxynucleotides available for reverse transcription in myeloid cells and resting T cells. Accordingly, transduction of these cells...

Descripción completa

Detalles Bibliográficos
Autores principales:	Reinhard, Christian, Bottinelli, Dario, Kim, Baek, Luban, Jeremy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923257/ https://www.ncbi.nlm.nih.gov/pubmed/24485168 http://dx.doi.org/10.1186/1742-4690-11-12

Ejemplares similares

Vpx rescue of HIV-1 from the antiviral state is independent of the intracellular nucleotide concentration
por: Reinhard, Christian, et al.
Publicado: (2013)

Vpx rescues HIV-1 transduction of dendritic cells from the antiviral state established by type 1 interferon
por: Pertel, Thomas, et al.
Publicado: (2011)

Primate immunodeficiency virus Vpx and Vpr counteract transcriptional repression of proviruses by the HUSH complex
por: Yurkovetskiy, Leonid, et al.
Publicado: (2018)

The HIV-2/SIV(SM )Vpx protein and an antiviral restriction in primary myeloid cells
por: Berger, Gregory, et al.
Publicado: (2009)

Vpx-Independent Lentiviral Transduction and shRNA-Mediated Protein Knock-Down in Monocyte-Derived Dendritic Cells
por: Witkowski, Wojciech, et al.
Publicado: (2015)

SAMHD1-Dependent and -Independent Functions of HIV-2/SIV Vpx Protein
por: Fujita, Mikako, et al.
Publicado: (2012)

Efficient, Vpx independent shRNA transduction of monocyte derived dendritic cells as a tool for studying HIV transmission to primary T-cells
por: Witkowski, Wojciech, et al.
Publicado: (2013)

Co-Evolution of Primate SAMHD1 and Lentivirus Vpx Leads to the Loss of the vpx Gene in HIV-1 Ancestor
por: Zhang, Chiyu, et al.
Publicado: (2012)

Vpx-containing Dendritic Cell Vaccine Vectors Induce CTLs and Reactivate Latent HIV-1 in vitro
por: Norton, Thomas D., et al.
Publicado: (2015)

Vpx enhances innate immune responses independently of SAMHD1 during HIV-1 infection
por: Cingöz, Oya, et al.
Publicado: (2021)

Regulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implications
por: Kohnken, Rebecca, et al.
Publicado: (2015)

A novel artificial intelligence-based approach for identification of deoxynucleotide aptamers
por: Heredia, Frances L., et al.
Publicado: (2021)

Silylation of Deoxynucleotide Analog Yields an Orally Available Drug with Antileukemia Effects
por: Ureshino, Hiroshi, et al.
Publicado: (2021)

Role of poly-proline motif in HIV-2 Vpx expression
por: Miyake, Ariko, et al.
Publicado: (2014)

Vpx is Critical for SIVmne infection of pigtail macaques
por: Belshan, Michael, et al.
Publicado: (2012)

Polymerase-catalyzed synthesis of DNA from phosphoramidate conjugates of deoxynucleotides and amino acids
por: Adelfinskaya, O., et al.
Publicado: (2007)

MPV17 Loss Causes Deoxynucleotide Insufficiency and Slow DNA Replication in Mitochondria
por: Dalla Rosa, Ilaria, et al.
Publicado: (2016)

Restriction of HIV-1 Replication in Monocytes Is Abolished by Vpx of SIVsmmPBj
por: Schüle, Silke, et al.
Publicado: (2009)

The Frequency of Cytidine Editing of Viral DNA Is Differentially Influenced by Vpx and Nucleosides during HIV-1 or SIV(MAC) Infection of Dendritic Cells
por: Nguyen, Xuan-Nhi, et al.
Publicado: (2015)

Molecular mechanisms of the interplay between Vpx and SAMHD1
por: Wu, Ying, et al.
Publicado: (2013)

SIV Vpx Is Essential for Macrophage Infection but Not for Development of AIDS
por: Westmoreland, Susan V., et al.
Publicado: (2014)

The feasibility of incorporating Vpx into lentiviral gene therapy vectors
por: McAllery, Samantha A, et al.
Publicado: (2016)

Mechanistic and Kinetic Differences between Reverse Transcriptases of Vpx Coding and Non-coding Lentiviruses
por: Lenzi, Gina M., et al.
Publicado: (2015)

Functional Characterization of drim2, the Drosophila melanogaster Homolog of the Yeast Mitochondrial Deoxynucleotide Transporter
por: Da-Rè, Caterina, et al.
Publicado: (2014)

N (6)-Substituted AMPs Inhibit Mammalian Deoxynucleotide N-Hydrolase DNPH1
por: Amiable, Claire, et al.
Publicado: (2013)

Characterization of the dynamics of Plasmodium falciparum deoxynucleotide-triphosphate pool in a stage-specific manner
por: Babai, Réka, et al.
Publicado: (2022)

Intracellular Regulation of Cross-Presentation during Dendritic Cell Maturation
por: Wagner, Claudia S., et al.
Publicado: (2013)

Correction: N (6)-Substituted AMPs Inhibit Mammalian Deoxynucleotide N-Hydrolase DNPH1
por: Amiable, Claire, et al.
Publicado: (2014)

SAMHD1 acetylation enhances its deoxynucleotide triphosphohydrolase activity and promotes cancer cell proliferation
por: Lee, Eun Ji, et al.
Publicado: (2017)

Enhanced systemic antilymphoma immune response by photothermal therapy with CpG deoxynucleotide–coated nanoparticles
por: Lin, Adam Yuh, et al.
Publicado: (2022)

SIV(SM)/HIV-2 Vpx proteins promote retroviral escape from a proteasome-dependent restriction pathway present in human dendritic cells
por: Goujon, Caroline, et al.
Publicado: (2007)

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein
por: Hrecka, Kasia, et al.
Publicado: (2011)

Limelight on two HIV/SIV accessory proteins in macrophage infection: Is Vpx overshadowing Vpr?
por: Ayinde, Diana, et al.
Publicado: (2010)

The role of SAMHD1 expression and its relation to HIV-2 (Vpx) gene production
por: Bakir, Talal M.
Publicado: (2018)

Binding to DCAF1 distinguishes TASOR and SAMHD1 degradation by HIV-2 Vpx
por: Martin, Michaël M., et al.
Publicado: (2021)

A Model for the Emergence of RNA from a Prebiotically Plausible Mixture of Ribonucleotides, Arabinonucleotides, and 2′-Deoxynucleotides
por: Kim, Seohyun Chris, et al.
Publicado: (2020)

Author Correction: Characterization of the dynamics of Plasmodium falciparum deoxynucleotide-triphosphate pool in a stage-specific manner
por: Babai, Réka, et al.
Publicado: (2023)

Back to the cell cycle with SAMHD1 and its viral antagonist, Vpx
por: Margottin-Goguet, Florence
Publicado: (2013)

HIV-2 Vpx neutralizes host restriction factor SAMHD1 to promote viral pathogenesis
por: Mohamed, Ahlam, et al.
Publicado: (2021)

HIV-2/SIV Vpx antagonises NF-κB activation by targeting p65
por: Fink, Douglas L., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_h033i0opja9nddn768nm8pj2bu