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Vpx rescue of HIV-1 from the antiviral state in mature dendritic cells is independent of the intracellular deoxynucleotide concentration

BACKGROUND: SIV(MAC)/HIV-2 Vpx recruits the CUL4A-DCAF1 E3 ubiquitin ligase complex to degrade the deoxynucleotide hydrolase SAMHD1. This increases the concentration of deoxynucleotides available for reverse transcription in myeloid cells and resting T cells. Accordingly, transduction of these cells...

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Detalles Bibliográficos
Autores principales:	Reinhard, Christian, Bottinelli, Dario, Kim, Baek, Luban, Jeremy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923257/ https://www.ncbi.nlm.nih.gov/pubmed/24485168 http://dx.doi.org/10.1186/1742-4690-11-12

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