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First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP(5) kinase

We synthesised analogues of diphosphoinositol polyphosphates (PP-InsPs) in which the diphosphate is replaced by an α-phosphonoacetic acid (PA) ester. Structural analysis revealed that 5-PA-InsP(5) mimics 5-PP-InsP(5) binding to the kinase domain of PPIP5K2; both molecules were phosphorylated by the...

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Detalles Bibliográficos
Autores principales:	Riley, Andrew M., Wang, Huanchen, Weaver, Jeremy D., Shears, Stephen B., Potter, Barry V. L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2012
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923271/ https://www.ncbi.nlm.nih.gov/pubmed/23032903 http://dx.doi.org/10.1039/c2cc36044f

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