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Phylogenetic analysis of CDK and cyclin proteins in premetazoan lineages

BACKGROUND: The molecular history of animal evolution from single-celled ancestors remains a major question in biology, and little is known regarding the evolution of cell cycle regulation during animal emergence. In this study, we conducted a comprehensive evolutionary analysis of CDK and cyclin pr...

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Autores principales: Cao, Lihuan, Chen, Fang, Yang, Xianmei, Xu, Weijin, Xie, Jun, Yu, Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923393/
https://www.ncbi.nlm.nih.gov/pubmed/24433236
http://dx.doi.org/10.1186/1471-2148-14-10
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author Cao, Lihuan
Chen, Fang
Yang, Xianmei
Xu, Weijin
Xie, Jun
Yu, Long
author_facet Cao, Lihuan
Chen, Fang
Yang, Xianmei
Xu, Weijin
Xie, Jun
Yu, Long
author_sort Cao, Lihuan
collection PubMed
description BACKGROUND: The molecular history of animal evolution from single-celled ancestors remains a major question in biology, and little is known regarding the evolution of cell cycle regulation during animal emergence. In this study, we conducted a comprehensive evolutionary analysis of CDK and cyclin proteins in metazoans and their unicellular relatives. RESULTS: Our analysis divided the CDK family into eight subfamilies. Seven subfamilies (CDK1/2/3, CDK5, CDK7, CDK 20, CDK8/19, CDK9, and CDK10/11) are conserved in metazoans and fungi, with the remaining subfamily, CDK4/6, found only in eumetazoans. With respect to cyclins, cyclin C, H, L, Y subfamilies, and cyclin K and T as a whole subfamily, are generally conserved in animal, fungi, and amoeba Dictyostelium discoideum. In contrast, cyclin subfamilies B, A, E, and D, which are cell cycle-related, have distinct evolutionary histories. The cyclin B subfamily is generally conserved in D. discoideum, fungi, and animals, whereas cyclin A and E subfamilies are both present in animals and their unicellular relatives such as choanoflagellate Monosiga brevicollis and filasterean Capsaspora owczarzaki, but are absent in fungi and D. discoideum. Although absent in fungi and D. discoideum, cyclin D subfamily orthologs can be found in the early-emerging, non-opisthokont apusozoan Thecamonas trahens. Within opisthokonta, the cyclin D subfamily is conserved only in eumetazoans, and is absent in fungi, choanoflagellates, and the basal metazoan Amphimedon queenslandica. CONCLUSIONS: Our data indicate that the CDK4/6 subfamily and eumetazoans emerged simultaneously, with the evolutionary conservation of the cyclin D subfamily also tightly linked with eumetazoan appearance. Establishment of the CDK4/6-cyclin D complex may have been the key step in the evolution of cell cycle control during eumetazoan emergence.
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spelling pubmed-39233932014-02-14 Phylogenetic analysis of CDK and cyclin proteins in premetazoan lineages Cao, Lihuan Chen, Fang Yang, Xianmei Xu, Weijin Xie, Jun Yu, Long BMC Evol Biol Research Article BACKGROUND: The molecular history of animal evolution from single-celled ancestors remains a major question in biology, and little is known regarding the evolution of cell cycle regulation during animal emergence. In this study, we conducted a comprehensive evolutionary analysis of CDK and cyclin proteins in metazoans and their unicellular relatives. RESULTS: Our analysis divided the CDK family into eight subfamilies. Seven subfamilies (CDK1/2/3, CDK5, CDK7, CDK 20, CDK8/19, CDK9, and CDK10/11) are conserved in metazoans and fungi, with the remaining subfamily, CDK4/6, found only in eumetazoans. With respect to cyclins, cyclin C, H, L, Y subfamilies, and cyclin K and T as a whole subfamily, are generally conserved in animal, fungi, and amoeba Dictyostelium discoideum. In contrast, cyclin subfamilies B, A, E, and D, which are cell cycle-related, have distinct evolutionary histories. The cyclin B subfamily is generally conserved in D. discoideum, fungi, and animals, whereas cyclin A and E subfamilies are both present in animals and their unicellular relatives such as choanoflagellate Monosiga brevicollis and filasterean Capsaspora owczarzaki, but are absent in fungi and D. discoideum. Although absent in fungi and D. discoideum, cyclin D subfamily orthologs can be found in the early-emerging, non-opisthokont apusozoan Thecamonas trahens. Within opisthokonta, the cyclin D subfamily is conserved only in eumetazoans, and is absent in fungi, choanoflagellates, and the basal metazoan Amphimedon queenslandica. CONCLUSIONS: Our data indicate that the CDK4/6 subfamily and eumetazoans emerged simultaneously, with the evolutionary conservation of the cyclin D subfamily also tightly linked with eumetazoan appearance. Establishment of the CDK4/6-cyclin D complex may have been the key step in the evolution of cell cycle control during eumetazoan emergence. BioMed Central 2014-01-17 /pmc/articles/PMC3923393/ /pubmed/24433236 http://dx.doi.org/10.1186/1471-2148-14-10 Text en Copyright © 2014 Cao et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Cao, Lihuan
Chen, Fang
Yang, Xianmei
Xu, Weijin
Xie, Jun
Yu, Long
Phylogenetic analysis of CDK and cyclin proteins in premetazoan lineages
title Phylogenetic analysis of CDK and cyclin proteins in premetazoan lineages
title_full Phylogenetic analysis of CDK and cyclin proteins in premetazoan lineages
title_fullStr Phylogenetic analysis of CDK and cyclin proteins in premetazoan lineages
title_full_unstemmed Phylogenetic analysis of CDK and cyclin proteins in premetazoan lineages
title_short Phylogenetic analysis of CDK and cyclin proteins in premetazoan lineages
title_sort phylogenetic analysis of cdk and cyclin proteins in premetazoan lineages
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923393/
https://www.ncbi.nlm.nih.gov/pubmed/24433236
http://dx.doi.org/10.1186/1471-2148-14-10
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