Cargando…

Effect of levofloxacin on neutrophilic airway inflammation in stable COPD: a randomized, double-blind, placebo-controlled trial

RATIONALE: Airway inflammation persists after smoking cessation in established chronic obstructive pulmonary disease (COPD), suggesting that other factors drive the airway inflammatory response. OBJECTIVES: We tested the hypothesis that high levels of bacterial colonization are associated with incre...

Descripción completa

Detalles Bibliográficos
Autores principales:	Siva, Roshan, Bafadhel, Mona, Monteiro, William, Brightling, Christopher E, Pavord, Ian D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2014
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923615/ https://www.ncbi.nlm.nih.gov/pubmed/24532969 http://dx.doi.org/10.2147/COPD.S55419

Ejemplares similares

Airway bacteria measured by quantitative polymerase chain reaction and culture in patients with stable COPD: relationship with neutrophilic airway inflammation, exacerbation frequency, and lung function
por: Bafadhel, Mona, et al.
Publicado: (2015)

Association Between Pathogens Detected Using Quantitative Polymerase Chain Reaction With Airway Inflammation in COPD at Stable State and Exacerbations
por: Barker, Bethan L., et al.
Publicado: (2015)

Neutrophil elastase as a biomarker for bacterial infection in COPD
por: Thulborn, Samantha J., et al.
Publicado: (2019)

The Effect of Azithromycin in Adults with Stable Neutrophilic COPD: A Double Blind Randomised, Placebo Controlled Trial
por: Simpson, Jodie L., et al.
Publicado: (2014)

Eosinophilic airway inflammation in COPD
por: Saha, Shironjit, et al.
Publicado: (2006)

The acute wheezy adult with airways disease in the emergency department: a retrospective case-note review of exacerbations of COPD
por: Russell, REK, et al.
Publicado: (2019)

The Role of CT Scanning in Multidimensional Phenotyping of COPD
por: Bafadhel, Mona, et al.
Publicado: (2011)

Eicosanoids and Eosinophilic Inflammation of Airways in Stable COPD
por: Celejewska-Wójcik, Natalia, et al.
Publicado: (2021)

CASCADE: a phase 2, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the effect of tezepelumab on airway inflammation in patients with uncontrolled asthma
por: Emson, Claire, et al.
Publicado: (2020)

COPD exacerbation severity and frequency is associated with impaired macrophage efferocytosis of eosinophils
por: Eltboli, Osama, et al.
Publicado: (2014)

Eosinophilic inflammation in COPD: from an inflammatory marker to a treatable trait
por: David, Benjamin, et al.
Publicado: (2021)

High serum granulocyte-colony stimulating factor characterises neutrophilic COPD exacerbations associated with dysbiosis
por: Chakrabarti, Arindam, et al.
Publicado: (2021)

Blood eosinophils to guide inhaled maintenance therapy in a primary care COPD population
por: Ashdown, Helen F., et al.
Publicado: (2021)

Investigating the role of pentraxin 3 as a biomarker for bacterial infection in subjects with COPD
por: Thulborn, Samantha J, et al.
Publicado: (2017)

Levofloxacin prophylaxis in patients with newly diagnosed myeloma (TEAMM): a multicentre, double-blind, placebo-controlled, randomised, phase 3 trial
por: Drayson, Mark T, et al.
Publicado: (2019)

The association between airway eosinophilic inflammation and IL-33 in stable non-atopic COPD
por: Tworek, Damian, et al.
Publicado: (2018)

Systemic and pulmonary inflammation is independent of skeletal muscle changes in patients with chronic obstructive pulmonary disease
por: Barker, Bethan L, et al.
Publicado: (2014)

Prevention of COPD exacerbation by lysozyme: a double-blind, randomized, placebo-controlled study
por: Fukuchi, Yoshinosuke, et al.
Publicado: (2016)

Airways Disease: Phenotyping Heterogeneity Using Measures of Airway Inflammation
por: Siddiqui, Salman, et al.
Publicado: (2007)

Body Mass and Fat Mass in Refractory Asthma: An Observational 1 Year Follow-Up Study
por: Bafadhel, Mona, et al.
Publicado: (2010)

Mepolizumab for Eosinophil-Associated COPD: Analysis of METREX and METREO
por: Pavord, Ian D, et al.
Publicado: (2021)

Creatine supplementation and physical training in patients with COPD: A double blind, placebo-controlled study
por: Faager, Gun, et al.
Publicado: (2006)

Working memory training efficacy in COPD: the randomised, double-blind, placebo-controlled Cogtrain trial
por: van Beers, Martijn, et al.
Publicado: (2021)

Procalcitonin and C-Reactive Protein in Hospitalized Adult Patients With Community-Acquired Pneumonia or Exacerbation of Asthma or COPD
por: Bafadhel, Mona, et al.
Publicado: (2011)

Detection of Cell-Dissociated Non-Typeable Haemophilus influenzae in the Airways of Patients with Chronic Obstructive Pulmonary Disease
por: Thulborn, Samantha J, et al.
Publicado: (2020)

Effect of acetazolamide on pulmonary vascular haemodynamics in patients with COPD going to altitude: a randomised, placebo-controlled, double-blind trial
por: Lichtblau, Mona, et al.
Publicado: (2023)

Concomitant therapy with Cineole (Eucalyptole) reduces exacerbations in COPD: A placebo-controlled double-blind trial
por: Worth, Heinrich, et al.
Publicado: (2009)

Expiratory central airway collapse in stable COPD and during exacerbations
por: Leong, Paul, et al.
Publicado: (2017)

Treating Neutrophilic Inflammation in Airways Diseases
por: Long, Merete B., et al.
Publicado: (2022)

Airway inflammation and mannitol challenge test in COPD
por: de Nijs, Selma B, et al.
Publicado: (2011)

The effect of vitamin D on COPD exacerbation: a double blind randomized placebo-controlled parallel clinical trial
por: Sanjari, Mojgan, et al.
Publicado: (2016)

Renaming COPD exacerbations: the UK respiratory nursing perspective
por: Mwasuku, Christine, et al.
Publicado: (2021)

Airway pathogens detected in stable and exacerbated COPD in patients in Asia-Pacific
por: Taddei, Laura, et al.
Publicado: (2022)

Bone Morphogenic Proteins and Their Antagonists in the Lower Airways of Stable COPD Patients
por: Di Stefano, Antonino, et al.
Publicado: (2023)

A Double-Blind, Randomized Placebo-Controlled Trial of Probiotic Lactobacillus casei Shirota in Stable Cirrhotic Patients
por: Macnaughtan, Jane, et al.
Publicado: (2020)

Vitamin D Supplementation Modulates Platelet-Mediated Inflammation in Subjects With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial
por: Johny, Ebin, et al.
Publicado: (2022)

Shall We Focus on the Eosinophil to Guide Treatment with Systemic Corticosteroids during Acute Exacerbations of COPD?: PRO
por: Camp, James, et al.
Publicado: (2018)

LAIR-1 Limits Neutrophilic Airway Inflammation
por: Kumawat, Kuldeep, et al.
Publicado: (2019)

Tracheostomy in children is associated with neutrophilic airway inflammation
por: Powell, Jason, et al.
Publicado: (2023)

Dexamethasone to prevent postextubation airway obstruction in adults: a prospective, randomized, double-blind, placebo-controlled study
por: Lee, Chao-Hsien, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_b9frlbv4jlr5j03sgg6b53nogq