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Uncovering the role of APC-Cdh1 in generating the dynamics of S-phase onset

Cdh1, a coactivator of the anaphase-promoting complex (APC), is a potential tumor suppressor. Cdh1 ablation promotes precocious S-phase entry, but it was unclear how this affects DNA replication dynamics while contributing to genomic instability and tumorigenesis. We find that Cdh1 depletion causes...

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Detalles Bibliográficos
Autores principales:	Yuan, Xi, Srividhya, Jeyaraman, De Luca, Thomas, Lee, Ju-hyong E., Pomerening, Joseph R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2014
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923637/ https://www.ncbi.nlm.nih.gov/pubmed/24356446 http://dx.doi.org/10.1091/mbc.E13-08-0480

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