Integrated Genomic Characterization Reveals Novel, Therapeutically Relevant Drug Targets in FGFR and EGFR Pathways in Sporadic Intrahepatic Cholangiocarcinoma

Advanced cholangiocarcinoma continues to harbor a difficult prognosis and therapeutic options have been limited. During the course of a clinical trial of whole genomic sequencing seeking druggable targets, we examined six patients with advanced cholangiocarcinoma. Integrated genome-wide and whole tr...

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Detalles Bibliográficos
Autores principales: Borad, Mitesh J., Champion, Mia D., Egan, Jan B., Liang, Winnie S., Fonseca, Rafael, Bryce, Alan H., McCullough, Ann E., Barrett, Michael T., Hunt, Katherine, Patel, Maitray D., Young, Scott W., Collins, Joseph M., Silva, Alvin C., Condjella, Rachel M., Block, Matthew, McWilliams, Robert R., Lazaridis, Konstantinos N., Klee, Eric W., Bible, Keith C., Harris, Pamela, Oliver, Gavin R., Bhavsar, Jaysheel D., Nair, Asha A., Middha, Sumit, Asmann, Yan, Kocher, Jean-Pierre, Schahl, Kimberly, Kipp, Benjamin R., Barr Fritcher, Emily G., Baker, Angela, Aldrich, Jessica, Kurdoglu, Ahmet, Izatt, Tyler, Christoforides, Alexis, Cherni, Irene, Nasser, Sara, Reiman, Rebecca, Phillips, Lori, McDonald, Jackie, Adkins, Jonathan, Mastrian, Stephen D., Placek, Pamela, Watanabe, Aprill T., LoBello, Janine, Han, Haiyong, Von Hoff, Daniel, Craig, David W., Stewart, A. Keith, Carpten, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923676/
https://www.ncbi.nlm.nih.gov/pubmed/24550739
http://dx.doi.org/10.1371/journal.pgen.1004135

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