A Monoallelic Deletion of the TcCRT Gene Increases the Attenuation of a Cultured Trypanosoma cruzi Strain, Protecting against an In Vivo Virulent Challenge

Trypanosoma cruzi calreticulin (TcCRT) is a virulence factor that binds complement C1, thus inhibiting the activation of the classical complement pathway and generating pro-phagocytic signals that increase parasite infectivity. In a previous work, we characterized a clonal cell line lacking one TcCR...

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Detalles Bibliográficos
Autores principales: Sánchez-Valdéz, Fernando J., Pérez Brandán, Cecilia, Ramírez, Galia, Uncos, Alejandro D., Zago, M. Paola, Cimino, Rubén O., Cardozo, Rubén M., Marco, Jorge D., Ferreira, Arturo, Basombrío, Miguel Ángel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923724/
https://www.ncbi.nlm.nih.gov/pubmed/24551259
http://dx.doi.org/10.1371/journal.pntd.0002696

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