Exocyst proteins in cytokinesis: Regulation by Rab11

The Exocyst is an octameric protein complex comprised of Sec3, Sec5, Sec6, Sec8, Sec10, Sec15, Exo70, and Exo84 subunits.(1, 2) This complex was first identified in budding yeast where it acts to target vesicles to the bud tip and the cleavage furrow.(3) Here, we show that all Exocyst subunits are r...

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Detalles Bibliográficos
Autores principales: Neto, Hélia, Balmer, Gemma, Gould, Gwyn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923785/
https://www.ncbi.nlm.nih.gov/pubmed/24563720
http://dx.doi.org/10.4161/cib.27635
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author Neto, Hélia
Balmer, Gemma
Gould, Gwyn
author_facet Neto, Hélia
Balmer, Gemma
Gould, Gwyn
author_sort Neto, Hélia
collection PubMed
description The Exocyst is an octameric protein complex comprised of Sec3, Sec5, Sec6, Sec8, Sec10, Sec15, Exo70, and Exo84 subunits.(1, 2) This complex was first identified in budding yeast where it acts to target vesicles to the bud tip and the cleavage furrow.(3) Here, we show that all Exocyst subunits are required for cytokinesis in mammalian cells. We further show that a subset of Exocyst proteins are differentially regulated by Rab11, consistent with recent studies implicating Rab11 vesicles in Exocyst protein trafficking.
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spelling pubmed-39237852014-02-21 Exocyst proteins in cytokinesis: Regulation by Rab11 Neto, Hélia Balmer, Gemma Gould, Gwyn Commun Integr Biol Short Communication The Exocyst is an octameric protein complex comprised of Sec3, Sec5, Sec6, Sec8, Sec10, Sec15, Exo70, and Exo84 subunits.(1, 2) This complex was first identified in budding yeast where it acts to target vesicles to the bud tip and the cleavage furrow.(3) Here, we show that all Exocyst subunits are required for cytokinesis in mammalian cells. We further show that a subset of Exocyst proteins are differentially regulated by Rab11, consistent with recent studies implicating Rab11 vesicles in Exocyst protein trafficking. Landes Bioscience 2013-11-01 2014-01-08 /pmc/articles/PMC3923785/ /pubmed/24563720 http://dx.doi.org/10.4161/cib.27635 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Short Communication
Neto, Hélia
Balmer, Gemma
Gould, Gwyn
Exocyst proteins in cytokinesis: Regulation by Rab11
title Exocyst proteins in cytokinesis: Regulation by Rab11
title_full Exocyst proteins in cytokinesis: Regulation by Rab11
title_fullStr Exocyst proteins in cytokinesis: Regulation by Rab11
title_full_unstemmed Exocyst proteins in cytokinesis: Regulation by Rab11
title_short Exocyst proteins in cytokinesis: Regulation by Rab11
title_sort exocyst proteins in cytokinesis: regulation by rab11
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923785/
https://www.ncbi.nlm.nih.gov/pubmed/24563720
http://dx.doi.org/10.4161/cib.27635
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AT balmergemma exocystproteinsincytokinesisregulationbyrab11
AT gouldgwyn exocystproteinsincytokinesisregulationbyrab11

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