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Loss of Drosophila Ataxin-7, a SAGA subunit, reduces H2B ubiquitination and leads to neural and retinal degeneration

The Spt–Ada–Gcn5–acetyltransferase (SAGA) chromatin-modifying complex possesses acetyltransferase and deubiquitinase activities. Within this modular complex, Ataxin-7 anchors the deubiquitinase activity to the larger complex. Here we identified and characterized Drosophila Ataxin-7 and found that re...

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Detalles Bibliográficos
Autores principales:	Mohan, Ryan D., Dialynas, George, Weake, Vikki M., Liu, Jianqi, Martin-Brown, Skylar, Florens, Laurence, Washburn, Michael P., Workman, Jerry L., Abmayr, Susan M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923968/ https://www.ncbi.nlm.nih.gov/pubmed/24493646 http://dx.doi.org/10.1101/gad.225151.113

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