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Orexin-1 receptor blockade dysregulates REM sleep in the presence of orexin-2 receptor antagonism

In accordance with the prominent role of orexins in the maintenance of wakefulness via activation of orexin-1 (OX1R) and orexin-2 (OX2R) receptors, various dual OX1/2R antagonists have been shown to promote sleep in animals and humans. While selective blockade of OX2R seems to be sufficient to initi...

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Detalles Bibliográficos
Autores principales:	Dugovic, Christine, Shelton, Jonathan E., Yun, Sujin, Bonaventure, Pascal, Shireman, Brock T., Lovenberg, Timothy W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2014
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924048/ https://www.ncbi.nlm.nih.gov/pubmed/24592208 http://dx.doi.org/10.3389/fnins.2014.00028

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