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Current Understanding on the Molecular Basis of Chondrogenesis
Endochondral bone formation involves multiple steps, consisting of the condensation of undifferentiated mesenchymal cells, proliferation and hypertrophic differentiation of chondrocytes, and then mineralization. To date, various factors including transcription factors, soluble mediators, extracellul...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Japanese Society for Pediatric Endocrinology
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924171/ https://www.ncbi.nlm.nih.gov/pubmed/24532955 http://dx.doi.org/10.1297/cpe.23.1 |
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author | Michigami, Toshimi |
author_facet | Michigami, Toshimi |
author_sort | Michigami, Toshimi |
collection | PubMed |
description | Endochondral bone formation involves multiple steps, consisting of the condensation of undifferentiated mesenchymal cells, proliferation and hypertrophic differentiation of chondrocytes, and then mineralization. To date, various factors including transcription factors, soluble mediators, extracellular matrices (ECMs), and cell-cell and cell-matrix interactions have been identified to regulate this sequential, complex process. Moreover, recent studies have revealed that epigenetic and microRNA-mediated mechanisms also play roles in chondrogenesis. Defects in the regulators for the development of growth plate cartilage often cause skeletal dysplasias and growth failure. In this review article, I will describe the current understanding concerning the regulatory mechanisms underlying chondrogenesis. |
format | Online Article Text |
id | pubmed-3924171 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | The Japanese Society for Pediatric Endocrinology |
record_format | MEDLINE/PubMed |
spelling | pubmed-39241712014-02-14 Current Understanding on the Molecular Basis of Chondrogenesis Michigami, Toshimi Clin Pediatr Endocrinol Review Article Endochondral bone formation involves multiple steps, consisting of the condensation of undifferentiated mesenchymal cells, proliferation and hypertrophic differentiation of chondrocytes, and then mineralization. To date, various factors including transcription factors, soluble mediators, extracellular matrices (ECMs), and cell-cell and cell-matrix interactions have been identified to regulate this sequential, complex process. Moreover, recent studies have revealed that epigenetic and microRNA-mediated mechanisms also play roles in chondrogenesis. Defects in the regulators for the development of growth plate cartilage often cause skeletal dysplasias and growth failure. In this review article, I will describe the current understanding concerning the regulatory mechanisms underlying chondrogenesis. The Japanese Society for Pediatric Endocrinology 2014-02-03 2014-01 /pmc/articles/PMC3924171/ /pubmed/24532955 http://dx.doi.org/10.1297/cpe.23.1 Text en 2014©The Japanese Society for Pediatric Endocrinology http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. |
spellingShingle | Review Article Michigami, Toshimi Current Understanding on the Molecular Basis of Chondrogenesis |
title | Current Understanding on the Molecular Basis of
Chondrogenesis |
title_full | Current Understanding on the Molecular Basis of
Chondrogenesis |
title_fullStr | Current Understanding on the Molecular Basis of
Chondrogenesis |
title_full_unstemmed | Current Understanding on the Molecular Basis of
Chondrogenesis |
title_short | Current Understanding on the Molecular Basis of
Chondrogenesis |
title_sort | current understanding on the molecular basis of
chondrogenesis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924171/ https://www.ncbi.nlm.nih.gov/pubmed/24532955 http://dx.doi.org/10.1297/cpe.23.1 |
work_keys_str_mv | AT michigamitoshimi currentunderstandingonthemolecularbasisofchondrogenesis |