Genetic inactivation and pharmacological blockade of sigma-1 receptors prevent paclitaxel-induced sensory-nerve mitochondrial abnormalities and neuropathic pain in mice

BACKGROUND: Paclitaxel, a widely-used antineoplastic drug, produces a painful peripheral neuropathy that in rodents is associated with peripheral-nerve mitochondrial alterations. The sigma-1 receptor (σ(1)R) is a ligand-regulated molecular chaperone involved in mitochondrial calcium homeostasis and...

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Detalles Bibliográficos
Autores principales: Nieto, Francisco R, Cendán, Cruz M, Cañizares, Francisco J, Cubero, María A, Vela, José M, Fernández-Segura, Eduardo, Baeyens, José M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924235/
https://www.ncbi.nlm.nih.gov/pubmed/24517272
http://dx.doi.org/10.1186/1744-8069-10-11

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