p53/TAp63 and AKT Regulate Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling through Two Independent Parallel Pathways in the Presence of DNA Damage

Under conditions of DNA damage, the mammalian target of rapamycin complex 1 (mTORC1) is inhibited, preventing cell cycle progression and conserving cellular energy by suppressing translation. We show that suppression of mTORC1 signaling to 4E-BP1 requires the coordinated activity of two tumor suppre...

Descripción completa

Detalles Bibliográficos
Autores principales: Cam, Maren, Bid, Hemant K., Xiao, Linlin, Zambetti, Gerard P., Houghton, Peter J., Cam, Hakan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924274/
https://www.ncbi.nlm.nih.gov/pubmed/24366874
http://dx.doi.org/10.1074/jbc.M113.530303

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924274/
https://www.ncbi.nlm.nih.gov/pubmed/24366874
http://dx.doi.org/10.1074/jbc.M113.530303

Ejemplares similares