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p53/TAp63 and AKT Regulate Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling through Two Independent Parallel Pathways in the Presence of DNA Damage

Under conditions of DNA damage, the mammalian target of rapamycin complex 1 (mTORC1) is inhibited, preventing cell cycle progression and conserving cellular energy by suppressing translation. We show that suppression of mTORC1 signaling to 4E-BP1 requires the coordinated activity of two tumor suppre...

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Detalles Bibliográficos
Autores principales:	Cam, Maren, Bid, Hemant K., Xiao, Linlin, Zambetti, Gerard P., Houghton, Peter J., Cam, Hakan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2014
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924274/ https://www.ncbi.nlm.nih.gov/pubmed/24366874 http://dx.doi.org/10.1074/jbc.M113.530303

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