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Analysis of the Hippocampal Proteome in ME7 Prion Disease Reveals a Predominant Astrocytic Signature and Highlights the Brain-restricted Production of Clusterin in Chronic Neurodegeneration

Prion diseases are characterized by accumulation of misfolded protein, gliosis, synaptic dysfunction, and ultimately neuronal loss. This sequence, mirroring key features of Alzheimer disease, is modeled well in ME7 prion disease. We used iTRAQ(TM)/mass spectrometry to compare the hippocampal proteom...

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Detalles Bibliográficos
Autores principales:	Asuni, Ayodeji A., Gray, Bryony, Bailey, Joanne, Skipp, Paul, Perry, V. Hugh, O'Connor, Vincent
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2014
Materias:	Neurobiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924314/ https://www.ncbi.nlm.nih.gov/pubmed/24366862 http://dx.doi.org/10.1074/jbc.M113.502690

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