The E3 ubiquitin ligases β-TrCP and FBXW7 cooperatively mediates GSK3-dependent Mcl-1 degradation induced by the Akt inhibitor API-1, resulting in apoptosis

BACKGROUND: The novel Akt inhibitor, API-1, induces apoptosis through undefined mechanisms. The current study focuses on revealing the mechanisms by which API-1 induces apoptosis. RESULTS: API-1 rapidly and potently reduced the levels of Mcl-1 primarily in API-1-senstive lung cancer cell lines. Ecto...

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Detalles Bibliográficos
Autores principales: Ren, Hui, Koo, Junghui, Guan, Baoxiang, Yue, Ping, Deng, Xingming, Chen, Mingwei, Khuri, Fadlo R, Sun, Shi-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924345/
https://www.ncbi.nlm.nih.gov/pubmed/24261825
http://dx.doi.org/10.1186/1476-4598-12-146

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