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The Function of E-Cadherin in Stem Cell Pluripotency and Self-Renewal

Embryonic stem (ES) and induced-pluripotent stem (iPS) cells can be grown indefinitely under appropriate conditions whilst retaining the ability to differentiate to cells representative of the three primary germ layers. Such cells have the potential to revolutionize medicine by offering treatment op...

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Detalles Bibliográficos
Autores principales: Soncin, Francesca, Ward, Christopher M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924836/
https://www.ncbi.nlm.nih.gov/pubmed/24710147
http://dx.doi.org/10.3390/genes2010229
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author Soncin, Francesca
Ward, Christopher M.
author_facet Soncin, Francesca
Ward, Christopher M.
author_sort Soncin, Francesca
collection PubMed
description Embryonic stem (ES) and induced-pluripotent stem (iPS) cells can be grown indefinitely under appropriate conditions whilst retaining the ability to differentiate to cells representative of the three primary germ layers. Such cells have the potential to revolutionize medicine by offering treatment options for a wide range of diseases and disorders as well as providing a model system for elucidating mechanisms involved in development and disease. In recent years, evidence for the function of E-cadherin in regulating pluripotent and self-renewal signaling pathways in ES and iPS cells has emerged. In this review, we discuss the function of E-cadherin and its interacting partners in the context of development and disease. We then describe relevant literature highlighting the function of E-cadherin in establishing and maintaining pluripotent and self-renewal properties of ES and iPS cells. In addition, we present experimental data demonstrating that exposure of human ES cells to the E-cadherin neutralizing antibody SHE78.7 allows culture of these cells in the absence of FGF2-supplemented medium.
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spelling pubmed-39248362014-03-26 The Function of E-Cadherin in Stem Cell Pluripotency and Self-Renewal Soncin, Francesca Ward, Christopher M. Genes (Basel) Review Embryonic stem (ES) and induced-pluripotent stem (iPS) cells can be grown indefinitely under appropriate conditions whilst retaining the ability to differentiate to cells representative of the three primary germ layers. Such cells have the potential to revolutionize medicine by offering treatment options for a wide range of diseases and disorders as well as providing a model system for elucidating mechanisms involved in development and disease. In recent years, evidence for the function of E-cadherin in regulating pluripotent and self-renewal signaling pathways in ES and iPS cells has emerged. In this review, we discuss the function of E-cadherin and its interacting partners in the context of development and disease. We then describe relevant literature highlighting the function of E-cadherin in establishing and maintaining pluripotent and self-renewal properties of ES and iPS cells. In addition, we present experimental data demonstrating that exposure of human ES cells to the E-cadherin neutralizing antibody SHE78.7 allows culture of these cells in the absence of FGF2-supplemented medium. MDPI 2011-02-25 /pmc/articles/PMC3924836/ /pubmed/24710147 http://dx.doi.org/10.3390/genes2010229 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Soncin, Francesca
Ward, Christopher M.
The Function of E-Cadherin in Stem Cell Pluripotency and Self-Renewal
title The Function of E-Cadherin in Stem Cell Pluripotency and Self-Renewal
title_full The Function of E-Cadherin in Stem Cell Pluripotency and Self-Renewal
title_fullStr The Function of E-Cadherin in Stem Cell Pluripotency and Self-Renewal
title_full_unstemmed The Function of E-Cadherin in Stem Cell Pluripotency and Self-Renewal
title_short The Function of E-Cadherin in Stem Cell Pluripotency and Self-Renewal
title_sort function of e-cadherin in stem cell pluripotency and self-renewal
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924836/
https://www.ncbi.nlm.nih.gov/pubmed/24710147
http://dx.doi.org/10.3390/genes2010229
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