Cargando…

A fragmented alignment method detects a putative phosphorylation site and a putative BRC repeat in the Drosophila melanogaster BRCA2 protein

Mutations in the BRCA2 tumor suppressor protein leave individuals susceptible to breast, ovarian and other cancers. The BRCA2 protein is a critical component of the DNA repair pathways in eukaryotes, and also plays an integral role in fostering genomic variability through meiotic recombination. Alth...

Descripción completa

Detalles Bibliográficos
Autor principal:	Chakraborty, Sandeep
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	F1000Research 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924952/ https://www.ncbi.nlm.nih.gov/pubmed/24627786 http://dx.doi.org/10.12688/f1000research.2-143.v2

Ejemplares similares

Effects of the Missense Mutations in Canine BRCA2 on BRC Repeat 3 Functions and Comparative Analyses between Canine and Human BRC Repeat 3
por: Yoshikawa, Yasunaga, et al.
Publicado: (2012)

A Highly Conserved Region in BRCA2 Suppresses the RAD51-Interaction Activity of BRC Repeats
por: Zhu, Zida, et al.
Publicado: (2023)

Two modules in the BRC repeats of BRCA2 mediate structural and functional interactions with the RAD51 recombinase
por: Rajendra, Eeson, et al.
Publicado: (2010)

Distinct binding of BRCA2 BRC repeats to RAD51 generates differential DNA damage sensitivity
por: Chatterjee, Gouri, et al.
Publicado: (2016)

Optimized Position Weight Matrices in Prediction of Novel Putative Binding Sites for Transcription Factors in the Drosophila melanogaster Genome
por: Morozov, Vyacheslav Y., et al.
Publicado: (2013)

A region of human BRCA2 containing multiple BRC repeats promotes RAD51-mediated strand exchange
por: Shivji, Mahmud K. K., et al.
Publicado: (2006)

A putative de novo evolved gene required for spermatid chromatin condensation in Drosophila melanogaster
por: Rivard, Emily L., et al.
Publicado: (2021)

LUMP Is a Putative Double-Stranded RNA Binding Protein Required for Male Fertility in Drosophila melanogaster
por: Sanders, Charcacia, et al.
Publicado: (2011)

Functional Analysis of a Putative Target of Spatially Varying Selection in the Menin1 Gene of Drosophila melanogaster
por: Svetec, Nicolas, et al.
Publicado: (2018)

Divergent binding mode for a protozoan BRC repeat to RAD51
por: Pantelejevs, Teodors, et al.
Publicado: (2022)

Interrogation of the Protein-Protein Interactions between Human BRCA2 BRC Repeats and RAD51 Reveals Atomistic Determinants of Affinity
por: Cole, Daniel J., et al.
Publicado: (2011)

BRC criteria revised.
Publicado: (1996)

BRCA2 BRC missense variants disrupt RAD51-dependent DNA repair
por: Jimenez-Sainz, Judit, et al.
Publicado: (2022)

Identification and partial characterization of the enzyme of omega: one of five putative DPP IV genes in Drosophila melanogaster
por: Chihara, Carol J., et al.
Publicado: (2005)

Trypanosoma brucei BRCA2 acts in antigenic variation and has undergone a recent expansion in BRC repeat number that is important during homologous recombination
por: Hartley, Claire L, et al.
Publicado: (2008)

A mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressor
por: Lee, M, et al.
Publicado: (2011)

Trypanosoma brucei BRCA2 acts in a life cycle-specific genome stability process and dictates BRC repeat number-dependent RAD51 subnuclear dynamics
por: Trenaman, Anna, et al.
Publicado: (2013)

Acute Downregulation of ENaC by EGF Involves the PY Motif and Putative ERK Phosphorylation Site
por: Falin, Rebecca A., et al.
Publicado: (2007)

Putative adaptive inter-slope divergence of transposon frequency in fruit flies (Drosophila melanogaster) at “Evolution Canyon”, Mount Carmel, Israel
por: Beiles, Avigdor, et al.
Publicado: (2015)

Neuromedin U and Its Putative Drosophila Homolog hugin
por: Melcher, Christoph, et al.
Publicado: (2006)

The Different Function of Single Phosphorylation Sites of Drosophila melanogaster Lamin Dm and Lamin C
por: Zaremba-Czogalla, Magdalena, et al.
Publicado: (2012)

Functional Interactions of Tau Phosphorylation Sites That Mediate Toxicity and Deficient Learning in Drosophila melanogaster
por: Keramidis, Iason, et al.
Publicado: (2020)

A study of somatic BRCA variants and their putative effect on protein properties in malignant mesothelioma
por: Krishnamurthy, Kritika, et al.
Publicado: (2023)

Isocitrate Dehydrogenase from Streptococcus mutans: Biochemical Properties and Evaluation of a Putative Phosphorylation Site at Ser102
por: Wang, Peng, et al.
Publicado: (2013)

Sex, mating and repeatability of Drosophila melanogaster longevity
por: Hoffman, Jessica M., et al.
Publicado: (2021)

PKC putative phosphorylation site Ser(235) is required for MIP/AQP0 translocation to the plasma membrane
por: Golestaneh, Nady, et al.
Publicado: (2008)

Impacts of Sub-lethal DDT Exposures on microRNA and Putative Target Transcript Expression in DDT Resistant and Susceptible Drosophila melanogaster Strains
por: Seong, Keon Mook, et al.
Publicado: (2019)

Structural and functional characterization of a putative de novo gene in Drosophila
por: Lange, Andreas, et al.
Publicado: (2021)

Hundreds of putatively functional small open reading frames in Drosophila
por: Ladoukakis, Emmanuel, et al.
Publicado: (2011)

Novel HSAN1 Mutation in Serine Palmitoyltransferase Resides at a Putative Phosphorylation Site That Is Involved in Regulating Substrate Specificity
por: Ernst, Daniela, et al.
Publicado: (2015)

Characterisation of homologues of known and putative dynein assembly factors in a Drosophila model
por: Lage, P zur, et al.
Publicado: (2015)

Mutations in CG8878, a Novel Putative Protein Kinase, Enhance P Element Dependent Silencing (PDS) and Position Effect Variegation (PEV) in Drosophila melanogaster
por: McCracken, Allen, et al.
Publicado: (2014)

Gut microbiota and their putative metabolic functions in fragmented Bengal tiger population of Nepal
por: Karmacharya, Dibesh, et al.
Publicado: (2019)

Neuronal Constituents and Putative Interactions Within the Drosophila Ellipsoid Body Neuropil
por: Omoto, Jaison Jiro, et al.
Publicado: (2018)

Ku Stabilizes Replication Forks in the Absence of Brc1
por: Sánchez, Arancha, et al.
Publicado: (2015)

Ablating putative Ku70 phosphorylation sites results in defective DNA damage repair and spontaneous induction of hepatocellular carcinoma
por: Saha, Janapriya, et al.
Publicado: (2021)

Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1
por: Ehlén, Åsa, et al.
Publicado: (2020)

Beyond phosphorylation: Putative roles of post-translational modifications in Plasmodium sexual stages
por: Johnson, Nila, et al.
Publicado: (2021)

An Analysis of the Putative CBD Binding Site in the Ionotropic Cannabinoid Receptors
por: Muller, Chanté, et al.
Publicado: (2020)

Design of Potent Inhibitors of Human RAD51 Recombinase Based on BRC Motifs of BRCA2 Protein: Modeling and Experimental Validation of a Chimera Peptide
por: Nomme, Julian, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_e47ja5v2qq4op5sqqd5jjadl90