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Dietary Phenolics as Reactive Carbonyl Scavengers: Potential Impact on Human Health and Mechanism of Action
Previous studies have demonstrated that accumulation of reactive carbonyl compounds in human tissue will accelerate the vascular damage in both diabetes and uremia. Moreover, advanced glycation progressively and irreversibly modify the proteins over time and yield advanced glycation end products (AG...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924986/ https://www.ncbi.nlm.nih.gov/pubmed/24716169 http://dx.doi.org/10.4103/2225-4110.114892 |
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author | Ho, Chi-Tang Wang, Mingfu |
author_facet | Ho, Chi-Tang Wang, Mingfu |
author_sort | Ho, Chi-Tang |
collection | PubMed |
description | Previous studies have demonstrated that accumulation of reactive carbonyl compounds in human tissue will accelerate the vascular damage in both diabetes and uremia. Moreover, advanced glycation progressively and irreversibly modify the proteins over time and yield advanced glycation end products (AGEs). AGEs are thought to contribute to the development of diabetes mellitus and its complications. Therefore, we propose a novel approach to decrease the levels of dicarbonyl compounds by direct trapping of dietary polyphenolic compounds, and consequently, inhibit the formation of AGEs and prevent the development of diabetic complications and age-related diseases. |
format | Online Article Text |
id | pubmed-3924986 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-39249862014-04-08 Dietary Phenolics as Reactive Carbonyl Scavengers: Potential Impact on Human Health and Mechanism of Action Ho, Chi-Tang Wang, Mingfu J Tradit Complement Med Perspective Previous studies have demonstrated that accumulation of reactive carbonyl compounds in human tissue will accelerate the vascular damage in both diabetes and uremia. Moreover, advanced glycation progressively and irreversibly modify the proteins over time and yield advanced glycation end products (AGEs). AGEs are thought to contribute to the development of diabetes mellitus and its complications. Therefore, we propose a novel approach to decrease the levels of dicarbonyl compounds by direct trapping of dietary polyphenolic compounds, and consequently, inhibit the formation of AGEs and prevent the development of diabetic complications and age-related diseases. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3924986/ /pubmed/24716169 http://dx.doi.org/10.4103/2225-4110.114892 Text en Copyright: © Journal of Traditional and Complementary Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Perspective Ho, Chi-Tang Wang, Mingfu Dietary Phenolics as Reactive Carbonyl Scavengers: Potential Impact on Human Health and Mechanism of Action |
title | Dietary Phenolics as Reactive Carbonyl Scavengers: Potential Impact on Human Health and Mechanism of Action |
title_full | Dietary Phenolics as Reactive Carbonyl Scavengers: Potential Impact on Human Health and Mechanism of Action |
title_fullStr | Dietary Phenolics as Reactive Carbonyl Scavengers: Potential Impact on Human Health and Mechanism of Action |
title_full_unstemmed | Dietary Phenolics as Reactive Carbonyl Scavengers: Potential Impact on Human Health and Mechanism of Action |
title_short | Dietary Phenolics as Reactive Carbonyl Scavengers: Potential Impact on Human Health and Mechanism of Action |
title_sort | dietary phenolics as reactive carbonyl scavengers: potential impact on human health and mechanism of action |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924986/ https://www.ncbi.nlm.nih.gov/pubmed/24716169 http://dx.doi.org/10.4103/2225-4110.114892 |
work_keys_str_mv | AT hochitang dietaryphenolicsasreactivecarbonylscavengerspotentialimpactonhumanhealthandmechanismofaction AT wangmingfu dietaryphenolicsasreactivecarbonylscavengerspotentialimpactonhumanhealthandmechanismofaction |