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Effect of Cissampelos Pareira Leaves on Anxiety-like Behavior in Experimental Animals
The present study was undertaken to evaluate anxiolytic effect of 70% hydroethanolic extract of leaves of Cissampelos pareira in murine models. C. pareira (Menispermaceae) is rich in alkaloids, and phytochemical results showed that it contains alkaloids, flavanoids, terpenoids, steroids, etc., Anxio...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924988/ https://www.ncbi.nlm.nih.gov/pubmed/24716177 http://dx.doi.org/10.4103/2225-4110.114902 |
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author | Thakur, Priyanka Rana, Avtar Chand |
author_facet | Thakur, Priyanka Rana, Avtar Chand |
author_sort | Thakur, Priyanka |
collection | PubMed |
description | The present study was undertaken to evaluate anxiolytic effect of 70% hydroethanolic extract of leaves of Cissampelos pareira in murine models. C. pareira (Menispermaceae) is rich in alkaloids, and phytochemical results showed that it contains alkaloids, flavanoids, terpenoids, steroids, etc., Anxiolytic activity was evaluated by using elevated plus maze test (EPM), light dark (LandD) model, and forced swim test (FS) models in rats. The efficacy of extract (100, 200, 400 mg/kg) was compared with control as well as standard diazepam (DZ; 2 mg/kg, p.o.) in EPM, LandD model, and imipramine (IM; 2.5 mg/kg, p.o.) in FS model. The results showed that DZ and extract significantly increased the number of entries, time spent in open arm, head dip counts, and rearing time, while they decreased fecal count in EPM. DZ and extract also significantly increased the number of crossings and time spent in light compartment, while they decreased duration of immobility in LandD model. In case of FS model, IM and extract significantly increased mobility and swimming time. Thus, the results confirm that hydroethanolic extract of C. pareira has the potential to be used in the management of anxiety-like behavior in a dose of 200 and 400 mg/kg. Further study is required to explore the plant and its parts for anxiolytic potential. |
format | Online Article Text |
id | pubmed-3924988 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-39249882014-04-08 Effect of Cissampelos Pareira Leaves on Anxiety-like Behavior in Experimental Animals Thakur, Priyanka Rana, Avtar Chand J Tradit Complement Med Original Research Paper The present study was undertaken to evaluate anxiolytic effect of 70% hydroethanolic extract of leaves of Cissampelos pareira in murine models. C. pareira (Menispermaceae) is rich in alkaloids, and phytochemical results showed that it contains alkaloids, flavanoids, terpenoids, steroids, etc., Anxiolytic activity was evaluated by using elevated plus maze test (EPM), light dark (LandD) model, and forced swim test (FS) models in rats. The efficacy of extract (100, 200, 400 mg/kg) was compared with control as well as standard diazepam (DZ; 2 mg/kg, p.o.) in EPM, LandD model, and imipramine (IM; 2.5 mg/kg, p.o.) in FS model. The results showed that DZ and extract significantly increased the number of entries, time spent in open arm, head dip counts, and rearing time, while they decreased fecal count in EPM. DZ and extract also significantly increased the number of crossings and time spent in light compartment, while they decreased duration of immobility in LandD model. In case of FS model, IM and extract significantly increased mobility and swimming time. Thus, the results confirm that hydroethanolic extract of C. pareira has the potential to be used in the management of anxiety-like behavior in a dose of 200 and 400 mg/kg. Further study is required to explore the plant and its parts for anxiolytic potential. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3924988/ /pubmed/24716177 http://dx.doi.org/10.4103/2225-4110.114902 Text en Copyright: © Journal of Traditional and Complementary Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Paper Thakur, Priyanka Rana, Avtar Chand Effect of Cissampelos Pareira Leaves on Anxiety-like Behavior in Experimental Animals |
title | Effect of Cissampelos Pareira Leaves on Anxiety-like Behavior in Experimental Animals |
title_full | Effect of Cissampelos Pareira Leaves on Anxiety-like Behavior in Experimental Animals |
title_fullStr | Effect of Cissampelos Pareira Leaves on Anxiety-like Behavior in Experimental Animals |
title_full_unstemmed | Effect of Cissampelos Pareira Leaves on Anxiety-like Behavior in Experimental Animals |
title_short | Effect of Cissampelos Pareira Leaves on Anxiety-like Behavior in Experimental Animals |
title_sort | effect of cissampelos pareira leaves on anxiety-like behavior in experimental animals |
topic | Original Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924988/ https://www.ncbi.nlm.nih.gov/pubmed/24716177 http://dx.doi.org/10.4103/2225-4110.114902 |
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