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The Pestivirus N Terminal Protease N(pro) Redistributes to Mitochondria and Peroxisomes Suggesting New Sites for Regulation of IRF3 by N(pro)

The N-terminal protease of pestiviruses, N(pro) is a unique viral protein, both because it is a distinct autoprotease that cleaves itself from the following polyprotein chain, and also because it binds and inactivates IRF3, a central regulator of interferon production. An important question remains...

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Detalles Bibliográficos
Autores principales: Jefferson, Matthew, Whelband, Matthew, Mohorianu, Irina, Powell, Penny P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925175/
https://www.ncbi.nlm.nih.gov/pubmed/24551175
http://dx.doi.org/10.1371/journal.pone.0088838