Functional Relevance of AcrB Trimerization in Pump Assembly and Substrate Binding

AcrB is a multidrug transporter in the inner membrane of Escherichia coli. It is an obligate homotrimer and forms a tripartite efflux complex with AcrA and TolC. AcrB is the engine of the efflux machinery and determines substrate specificity. Active efflux depends on several functional features incl...

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Detalles Bibliográficos
Autores principales: Lu, Wei, Zhong, Meng, Chai, Qian, Wang, Zhaoshuai, Yu, Linliang, Wei, Yinan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925222/
https://www.ncbi.nlm.nih.gov/pubmed/24551234
http://dx.doi.org/10.1371/journal.pone.0089143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925222/
https://www.ncbi.nlm.nih.gov/pubmed/24551234
http://dx.doi.org/10.1371/journal.pone.0089143

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