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Preoperative thrombocytosis is a significant unfavorable prognostic factor for patients with resectable non-small cell lung cancer

BACKGROUND: Previous studies have reported that pretreatment thrombocytosis is associated with poor outcomes in several cancer types. This study was designed to evaluate the prognostic significance of preoperative thrombocytosis in patients with non-small cell lung cancer (NSCLC) who undergo surgery...

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Autores principales: Kim, Miso, Chang, Hyun, Yang, Hee Chul, Kim, Yu Jung, Lee, Choon-Taek, Lee, Jae-Ho, Jheon, Sanghoon, Kim, Kwhanmien, Chung, Jin-Haeng, Lee, Jong Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925288/
https://www.ncbi.nlm.nih.gov/pubmed/24520974
http://dx.doi.org/10.1186/1477-7819-12-37
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author Kim, Miso
Chang, Hyun
Yang, Hee Chul
Kim, Yu Jung
Lee, Choon-Taek
Lee, Jae-Ho
Jheon, Sanghoon
Kim, Kwhanmien
Chung, Jin-Haeng
Lee, Jong Seok
author_facet Kim, Miso
Chang, Hyun
Yang, Hee Chul
Kim, Yu Jung
Lee, Choon-Taek
Lee, Jae-Ho
Jheon, Sanghoon
Kim, Kwhanmien
Chung, Jin-Haeng
Lee, Jong Seok
author_sort Kim, Miso
collection PubMed
description BACKGROUND: Previous studies have reported that pretreatment thrombocytosis is associated with poor outcomes in several cancer types. This study was designed to evaluate the prognostic significance of preoperative thrombocytosis in patients with non-small cell lung cancer (NSCLC) who undergo surgery. METHODS: We retrospectively reviewed the records of 199 patients who underwent R0 resection for NSCLC between May 2003 and July 2006 at Seoul National University Bundang Hospital, Seongnam, Korea. RESULTS: The frequency of preoperative thrombocytosis was 7.5% (15/199). Patients with preoperative thrombocytosis had shorter overall survival (OS, P = 0.003) and disease-free survival (DFS, P = 0.005) than those without thrombocytosis. In multivariable analysis, patients with preoperative thrombocytosis had a significantly greater risk of death and recurrence than those without preoperative thrombocytosis (risk of death: hazard ratio (HR) 2.98, 95% confidence interval (CI) 1.39 to 6.37, P = 0.005; risk of recurrence: HR 2.47, 95% CI 1.22 to 5.01, P = 0.012). A tendency towards a shorter OS and DFS was observed in three patients with persistent thrombocytosis during the follow-up period when compared with those of patients who recovered from thrombocytosis after surgery. CONCLUSIONS: Preoperative thrombocytosis was valuable for predicting the prognosis of patients with NSCLC. Special attention should be paid to patients with preoperative and postoperative thrombocytosis.
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spelling pubmed-39252882014-02-16 Preoperative thrombocytosis is a significant unfavorable prognostic factor for patients with resectable non-small cell lung cancer Kim, Miso Chang, Hyun Yang, Hee Chul Kim, Yu Jung Lee, Choon-Taek Lee, Jae-Ho Jheon, Sanghoon Kim, Kwhanmien Chung, Jin-Haeng Lee, Jong Seok World J Surg Oncol Research BACKGROUND: Previous studies have reported that pretreatment thrombocytosis is associated with poor outcomes in several cancer types. This study was designed to evaluate the prognostic significance of preoperative thrombocytosis in patients with non-small cell lung cancer (NSCLC) who undergo surgery. METHODS: We retrospectively reviewed the records of 199 patients who underwent R0 resection for NSCLC between May 2003 and July 2006 at Seoul National University Bundang Hospital, Seongnam, Korea. RESULTS: The frequency of preoperative thrombocytosis was 7.5% (15/199). Patients with preoperative thrombocytosis had shorter overall survival (OS, P = 0.003) and disease-free survival (DFS, P = 0.005) than those without thrombocytosis. In multivariable analysis, patients with preoperative thrombocytosis had a significantly greater risk of death and recurrence than those without preoperative thrombocytosis (risk of death: hazard ratio (HR) 2.98, 95% confidence interval (CI) 1.39 to 6.37, P = 0.005; risk of recurrence: HR 2.47, 95% CI 1.22 to 5.01, P = 0.012). A tendency towards a shorter OS and DFS was observed in three patients with persistent thrombocytosis during the follow-up period when compared with those of patients who recovered from thrombocytosis after surgery. CONCLUSIONS: Preoperative thrombocytosis was valuable for predicting the prognosis of patients with NSCLC. Special attention should be paid to patients with preoperative and postoperative thrombocytosis. BioMed Central 2014-02-12 /pmc/articles/PMC3925288/ /pubmed/24520974 http://dx.doi.org/10.1186/1477-7819-12-37 Text en Copyright © 2014 Kim et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Research
Kim, Miso
Chang, Hyun
Yang, Hee Chul
Kim, Yu Jung
Lee, Choon-Taek
Lee, Jae-Ho
Jheon, Sanghoon
Kim, Kwhanmien
Chung, Jin-Haeng
Lee, Jong Seok
Preoperative thrombocytosis is a significant unfavorable prognostic factor for patients with resectable non-small cell lung cancer
title Preoperative thrombocytosis is a significant unfavorable prognostic factor for patients with resectable non-small cell lung cancer
title_full Preoperative thrombocytosis is a significant unfavorable prognostic factor for patients with resectable non-small cell lung cancer
title_fullStr Preoperative thrombocytosis is a significant unfavorable prognostic factor for patients with resectable non-small cell lung cancer
title_full_unstemmed Preoperative thrombocytosis is a significant unfavorable prognostic factor for patients with resectable non-small cell lung cancer
title_short Preoperative thrombocytosis is a significant unfavorable prognostic factor for patients with resectable non-small cell lung cancer
title_sort preoperative thrombocytosis is a significant unfavorable prognostic factor for patients with resectable non-small cell lung cancer
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925288/
https://www.ncbi.nlm.nih.gov/pubmed/24520974
http://dx.doi.org/10.1186/1477-7819-12-37
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