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Preoperative thrombocytosis is a significant unfavorable prognostic factor for patients with resectable non-small cell lung cancer
BACKGROUND: Previous studies have reported that pretreatment thrombocytosis is associated with poor outcomes in several cancer types. This study was designed to evaluate the prognostic significance of preoperative thrombocytosis in patients with non-small cell lung cancer (NSCLC) who undergo surgery...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925288/ https://www.ncbi.nlm.nih.gov/pubmed/24520974 http://dx.doi.org/10.1186/1477-7819-12-37 |
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author | Kim, Miso Chang, Hyun Yang, Hee Chul Kim, Yu Jung Lee, Choon-Taek Lee, Jae-Ho Jheon, Sanghoon Kim, Kwhanmien Chung, Jin-Haeng Lee, Jong Seok |
author_facet | Kim, Miso Chang, Hyun Yang, Hee Chul Kim, Yu Jung Lee, Choon-Taek Lee, Jae-Ho Jheon, Sanghoon Kim, Kwhanmien Chung, Jin-Haeng Lee, Jong Seok |
author_sort | Kim, Miso |
collection | PubMed |
description | BACKGROUND: Previous studies have reported that pretreatment thrombocytosis is associated with poor outcomes in several cancer types. This study was designed to evaluate the prognostic significance of preoperative thrombocytosis in patients with non-small cell lung cancer (NSCLC) who undergo surgery. METHODS: We retrospectively reviewed the records of 199 patients who underwent R0 resection for NSCLC between May 2003 and July 2006 at Seoul National University Bundang Hospital, Seongnam, Korea. RESULTS: The frequency of preoperative thrombocytosis was 7.5% (15/199). Patients with preoperative thrombocytosis had shorter overall survival (OS, P = 0.003) and disease-free survival (DFS, P = 0.005) than those without thrombocytosis. In multivariable analysis, patients with preoperative thrombocytosis had a significantly greater risk of death and recurrence than those without preoperative thrombocytosis (risk of death: hazard ratio (HR) 2.98, 95% confidence interval (CI) 1.39 to 6.37, P = 0.005; risk of recurrence: HR 2.47, 95% CI 1.22 to 5.01, P = 0.012). A tendency towards a shorter OS and DFS was observed in three patients with persistent thrombocytosis during the follow-up period when compared with those of patients who recovered from thrombocytosis after surgery. CONCLUSIONS: Preoperative thrombocytosis was valuable for predicting the prognosis of patients with NSCLC. Special attention should be paid to patients with preoperative and postoperative thrombocytosis. |
format | Online Article Text |
id | pubmed-3925288 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-39252882014-02-16 Preoperative thrombocytosis is a significant unfavorable prognostic factor for patients with resectable non-small cell lung cancer Kim, Miso Chang, Hyun Yang, Hee Chul Kim, Yu Jung Lee, Choon-Taek Lee, Jae-Ho Jheon, Sanghoon Kim, Kwhanmien Chung, Jin-Haeng Lee, Jong Seok World J Surg Oncol Research BACKGROUND: Previous studies have reported that pretreatment thrombocytosis is associated with poor outcomes in several cancer types. This study was designed to evaluate the prognostic significance of preoperative thrombocytosis in patients with non-small cell lung cancer (NSCLC) who undergo surgery. METHODS: We retrospectively reviewed the records of 199 patients who underwent R0 resection for NSCLC between May 2003 and July 2006 at Seoul National University Bundang Hospital, Seongnam, Korea. RESULTS: The frequency of preoperative thrombocytosis was 7.5% (15/199). Patients with preoperative thrombocytosis had shorter overall survival (OS, P = 0.003) and disease-free survival (DFS, P = 0.005) than those without thrombocytosis. In multivariable analysis, patients with preoperative thrombocytosis had a significantly greater risk of death and recurrence than those without preoperative thrombocytosis (risk of death: hazard ratio (HR) 2.98, 95% confidence interval (CI) 1.39 to 6.37, P = 0.005; risk of recurrence: HR 2.47, 95% CI 1.22 to 5.01, P = 0.012). A tendency towards a shorter OS and DFS was observed in three patients with persistent thrombocytosis during the follow-up period when compared with those of patients who recovered from thrombocytosis after surgery. CONCLUSIONS: Preoperative thrombocytosis was valuable for predicting the prognosis of patients with NSCLC. Special attention should be paid to patients with preoperative and postoperative thrombocytosis. BioMed Central 2014-02-12 /pmc/articles/PMC3925288/ /pubmed/24520974 http://dx.doi.org/10.1186/1477-7819-12-37 Text en Copyright © 2014 Kim et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. |
spellingShingle | Research Kim, Miso Chang, Hyun Yang, Hee Chul Kim, Yu Jung Lee, Choon-Taek Lee, Jae-Ho Jheon, Sanghoon Kim, Kwhanmien Chung, Jin-Haeng Lee, Jong Seok Preoperative thrombocytosis is a significant unfavorable prognostic factor for patients with resectable non-small cell lung cancer |
title | Preoperative thrombocytosis is a significant unfavorable prognostic factor for patients with resectable non-small cell lung cancer |
title_full | Preoperative thrombocytosis is a significant unfavorable prognostic factor for patients with resectable non-small cell lung cancer |
title_fullStr | Preoperative thrombocytosis is a significant unfavorable prognostic factor for patients with resectable non-small cell lung cancer |
title_full_unstemmed | Preoperative thrombocytosis is a significant unfavorable prognostic factor for patients with resectable non-small cell lung cancer |
title_short | Preoperative thrombocytosis is a significant unfavorable prognostic factor for patients with resectable non-small cell lung cancer |
title_sort | preoperative thrombocytosis is a significant unfavorable prognostic factor for patients with resectable non-small cell lung cancer |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925288/ https://www.ncbi.nlm.nih.gov/pubmed/24520974 http://dx.doi.org/10.1186/1477-7819-12-37 |
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