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Effect of Electroacupuncture on Rats with Chronic Constriction Injury-Induced Neuropathic Pain

We adopt the chronic constriction injury (CCI) model to induce neuropathic pain to Spragrue-Dawley (SD) rats by ligating the right sciatic nerve of using four 4-0 chromic gut sutures and subsequently applying 2 and 15 Hz electroacupuncture (EA), respectively, to the right (ipsilateral) Zusanli (St-3...

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Autores principales: Hsu, Hsin-Cheng, Tang, Nou-Ying, Lin, Yi-Wen, Li, Tsai-Chung, Liu, Hsu-Jan, Hsieh, Ching-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925545/
https://www.ncbi.nlm.nih.gov/pubmed/24605047
http://dx.doi.org/10.1155/2014/129875
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author Hsu, Hsin-Cheng
Tang, Nou-Ying
Lin, Yi-Wen
Li, Tsai-Chung
Liu, Hsu-Jan
Hsieh, Ching-Liang
author_facet Hsu, Hsin-Cheng
Tang, Nou-Ying
Lin, Yi-Wen
Li, Tsai-Chung
Liu, Hsu-Jan
Hsieh, Ching-Liang
author_sort Hsu, Hsin-Cheng
collection PubMed
description We adopt the chronic constriction injury (CCI) model to induce neuropathic pain to Spragrue-Dawley (SD) rats by ligating the right sciatic nerve of using four 4-0 chromic gut sutures and subsequently applying 2 and 15 Hz electroacupuncture (EA), respectively, to the right (ipsilateral) Zusanli (St-36) and Shangjuxu (St-37) acupoints. The results of this study are summarized as follows: (1) the differences in withdrawal latencies for the radiant heat test and total lift leg counts for the cold plate test (4°C) of the control (i.e., non-EA) and sham groups were greater than those of the 2 Hz EA (2EA) and 15 Hz EA (15EA) groups; (2) the von Frey test filament gram counts of the control and sham groups were less than those of the 2EA and 15EA groups on the 6th, 7th, 8th, 11th, 12th, and 13th day following ligation; and (3) the 2EA and 15EA groups exhibited reduced cerebral transient receptor potential vanilloid type 4 (TRPV4) expressions, although we did not observe a similar effect for cerebral TRPV1 or spinal TRPV4/TRPV1 expressions. These findings show that 2 and 15 Hz EA can reduce CCI-induced neuropathic pain, which indicates that various spinal segmental and gate effects have a crucial function in pain reduction. The relationship between EA and TRPV4/TRPV1 expression requires further study.
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spelling pubmed-39255452014-03-06 Effect of Electroacupuncture on Rats with Chronic Constriction Injury-Induced Neuropathic Pain Hsu, Hsin-Cheng Tang, Nou-Ying Lin, Yi-Wen Li, Tsai-Chung Liu, Hsu-Jan Hsieh, Ching-Liang ScientificWorldJournal Research Article We adopt the chronic constriction injury (CCI) model to induce neuropathic pain to Spragrue-Dawley (SD) rats by ligating the right sciatic nerve of using four 4-0 chromic gut sutures and subsequently applying 2 and 15 Hz electroacupuncture (EA), respectively, to the right (ipsilateral) Zusanli (St-36) and Shangjuxu (St-37) acupoints. The results of this study are summarized as follows: (1) the differences in withdrawal latencies for the radiant heat test and total lift leg counts for the cold plate test (4°C) of the control (i.e., non-EA) and sham groups were greater than those of the 2 Hz EA (2EA) and 15 Hz EA (15EA) groups; (2) the von Frey test filament gram counts of the control and sham groups were less than those of the 2EA and 15EA groups on the 6th, 7th, 8th, 11th, 12th, and 13th day following ligation; and (3) the 2EA and 15EA groups exhibited reduced cerebral transient receptor potential vanilloid type 4 (TRPV4) expressions, although we did not observe a similar effect for cerebral TRPV1 or spinal TRPV4/TRPV1 expressions. These findings show that 2 and 15 Hz EA can reduce CCI-induced neuropathic pain, which indicates that various spinal segmental and gate effects have a crucial function in pain reduction. The relationship between EA and TRPV4/TRPV1 expression requires further study. Hindawi Publishing Corporation 2014-01-27 /pmc/articles/PMC3925545/ /pubmed/24605047 http://dx.doi.org/10.1155/2014/129875 Text en Copyright © 2014 Hsin-Cheng Hsu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Hsu, Hsin-Cheng
Tang, Nou-Ying
Lin, Yi-Wen
Li, Tsai-Chung
Liu, Hsu-Jan
Hsieh, Ching-Liang
Effect of Electroacupuncture on Rats with Chronic Constriction Injury-Induced Neuropathic Pain
title Effect of Electroacupuncture on Rats with Chronic Constriction Injury-Induced Neuropathic Pain
title_full Effect of Electroacupuncture on Rats with Chronic Constriction Injury-Induced Neuropathic Pain
title_fullStr Effect of Electroacupuncture on Rats with Chronic Constriction Injury-Induced Neuropathic Pain
title_full_unstemmed Effect of Electroacupuncture on Rats with Chronic Constriction Injury-Induced Neuropathic Pain
title_short Effect of Electroacupuncture on Rats with Chronic Constriction Injury-Induced Neuropathic Pain
title_sort effect of electroacupuncture on rats with chronic constriction injury-induced neuropathic pain
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925545/
https://www.ncbi.nlm.nih.gov/pubmed/24605047
http://dx.doi.org/10.1155/2014/129875
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