Annexin A2: Its Molecular Regulation and Cellular Expression in Cancer Development

Annexin A2 (ANXA2) orchestrates multiple biologic processes and clinical associations, especially in cancer progression. The structure of ANXA2 affects its cellular localization and function. However, posttranslational modification and protease-mediated N-terminal cleavage also play critical roles i...

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Detalles Bibliográficos
Autores principales: Wang, Chi-Yun, Lin, Chiou-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925611/
https://www.ncbi.nlm.nih.gov/pubmed/24591759
http://dx.doi.org/10.1155/2014/308976
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author Wang, Chi-Yun
Lin, Chiou-Feng
author_facet Wang, Chi-Yun
Lin, Chiou-Feng
author_sort Wang, Chi-Yun
collection PubMed
description Annexin A2 (ANXA2) orchestrates multiple biologic processes and clinical associations, especially in cancer progression. The structure of ANXA2 affects its cellular localization and function. However, posttranslational modification and protease-mediated N-terminal cleavage also play critical roles in regulating ANXA2. ANXA2 expression levels vary among different types of cancers. With some cancers, ANXA2 can be used for the detection and diagnosis of cancer and for monitoring cancer progression. ANXA2 is also required for drug-resistance. This review discusses the feasibility of ANXA2 which is active in cancer development and can be a therapeutic target in cancer management.
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spelling pubmed-39256112014-03-03 Annexin A2: Its Molecular Regulation and Cellular Expression in Cancer Development Wang, Chi-Yun Lin, Chiou-Feng Dis Markers Review Article Annexin A2 (ANXA2) orchestrates multiple biologic processes and clinical associations, especially in cancer progression. The structure of ANXA2 affects its cellular localization and function. However, posttranslational modification and protease-mediated N-terminal cleavage also play critical roles in regulating ANXA2. ANXA2 expression levels vary among different types of cancers. With some cancers, ANXA2 can be used for the detection and diagnosis of cancer and for monitoring cancer progression. ANXA2 is also required for drug-resistance. This review discusses the feasibility of ANXA2 which is active in cancer development and can be a therapeutic target in cancer management. Hindawi Publishing Corporation 2014 2014-01-23 /pmc/articles/PMC3925611/ /pubmed/24591759 http://dx.doi.org/10.1155/2014/308976 Text en Copyright © 2014 C.-Y. Wang and C.-F. Lin. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wang, Chi-Yun
Lin, Chiou-Feng
Annexin A2: Its Molecular Regulation and Cellular Expression in Cancer Development
title Annexin A2: Its Molecular Regulation and Cellular Expression in Cancer Development
title_full Annexin A2: Its Molecular Regulation and Cellular Expression in Cancer Development
title_fullStr Annexin A2: Its Molecular Regulation and Cellular Expression in Cancer Development
title_full_unstemmed Annexin A2: Its Molecular Regulation and Cellular Expression in Cancer Development
title_short Annexin A2: Its Molecular Regulation and Cellular Expression in Cancer Development
title_sort annexin a2: its molecular regulation and cellular expression in cancer development
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925611/
https://www.ncbi.nlm.nih.gov/pubmed/24591759
http://dx.doi.org/10.1155/2014/308976
work_keys_str_mv AT wangchiyun annexina2itsmolecularregulationandcellularexpressionincancerdevelopment
AT linchioufeng annexina2itsmolecularregulationandcellularexpressionincancerdevelopment

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