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Urine Annexin A1 as an Index for Glomerular Injury in Patients

Background. We recently demonstrated high urine levels of annexin A1 (ANXA1) protein in a mouse Adriamycin-induced glomerulopathy (ADG) model. Objective. To establish ANXA1 as a potential biomarker for glomerular injury in patients. Methods. A time-course study in the mouse ADG model, followed by re...

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Autores principales: Ka, Shuk-Man, Tsai, Pei-Yi, Chao, Tai-Kuang, Yang, Shun-Min, Hung, Yi-Jen, Chen, Jin-Shuen, Shui, Hao-Ai, Chen, Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925619/
https://www.ncbi.nlm.nih.gov/pubmed/24591769
http://dx.doi.org/10.1155/2014/854163
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author Ka, Shuk-Man
Tsai, Pei-Yi
Chao, Tai-Kuang
Yang, Shun-Min
Hung, Yi-Jen
Chen, Jin-Shuen
Shui, Hao-Ai
Chen, Ann
author_facet Ka, Shuk-Man
Tsai, Pei-Yi
Chao, Tai-Kuang
Yang, Shun-Min
Hung, Yi-Jen
Chen, Jin-Shuen
Shui, Hao-Ai
Chen, Ann
author_sort Ka, Shuk-Man
collection PubMed
description Background. We recently demonstrated high urine levels of annexin A1 (ANXA1) protein in a mouse Adriamycin-induced glomerulopathy (ADG) model. Objective. To establish ANXA1 as a potential biomarker for glomerular injury in patients. Methods. A time-course study in the mouse ADG model, followed by renal tissues and urine samples from patients with various types of glomerular disorders for ANXA1. Results. Urinary ANXA1 protein was (1) detectable in both the ADG model and in patients except those with minimal change disease (MCD); (2) positively correlated with renal lesions in patients; and (3) early detectable in diabetes patients with normoalbuminuria. Conclusions. ANXA1 is a universal biomarker that is helpful in the early diagnosis, prognostic prediction, and outcome monitoring of glomerular injury. Measurement of urinary ANXA1 protein levels can help in differentiating MCD from other types of glomerular disorders.
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spelling pubmed-39256192014-03-03 Urine Annexin A1 as an Index for Glomerular Injury in Patients Ka, Shuk-Man Tsai, Pei-Yi Chao, Tai-Kuang Yang, Shun-Min Hung, Yi-Jen Chen, Jin-Shuen Shui, Hao-Ai Chen, Ann Dis Markers Research Article Background. We recently demonstrated high urine levels of annexin A1 (ANXA1) protein in a mouse Adriamycin-induced glomerulopathy (ADG) model. Objective. To establish ANXA1 as a potential biomarker for glomerular injury in patients. Methods. A time-course study in the mouse ADG model, followed by renal tissues and urine samples from patients with various types of glomerular disorders for ANXA1. Results. Urinary ANXA1 protein was (1) detectable in both the ADG model and in patients except those with minimal change disease (MCD); (2) positively correlated with renal lesions in patients; and (3) early detectable in diabetes patients with normoalbuminuria. Conclusions. ANXA1 is a universal biomarker that is helpful in the early diagnosis, prognostic prediction, and outcome monitoring of glomerular injury. Measurement of urinary ANXA1 protein levels can help in differentiating MCD from other types of glomerular disorders. Hindawi Publishing Corporation 2014 2014-01-20 /pmc/articles/PMC3925619/ /pubmed/24591769 http://dx.doi.org/10.1155/2014/854163 Text en Copyright © 2014 Shuk-Man Ka et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ka, Shuk-Man
Tsai, Pei-Yi
Chao, Tai-Kuang
Yang, Shun-Min
Hung, Yi-Jen
Chen, Jin-Shuen
Shui, Hao-Ai
Chen, Ann
Urine Annexin A1 as an Index for Glomerular Injury in Patients
title Urine Annexin A1 as an Index for Glomerular Injury in Patients
title_full Urine Annexin A1 as an Index for Glomerular Injury in Patients
title_fullStr Urine Annexin A1 as an Index for Glomerular Injury in Patients
title_full_unstemmed Urine Annexin A1 as an Index for Glomerular Injury in Patients
title_short Urine Annexin A1 as an Index for Glomerular Injury in Patients
title_sort urine annexin a1 as an index for glomerular injury in patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925619/
https://www.ncbi.nlm.nih.gov/pubmed/24591769
http://dx.doi.org/10.1155/2014/854163
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