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Impact of tuberculosis treatment on health-related quality of life of pulmonary tuberculosis patients: a follow-up study

BACKGROUND: At present, much of the attention within tuberculosis (TB) management is spent on microbiological cure, and its impact on health-related quality of life (HRQoL) is either undervalued or seldom considered. The aim of this study was to evaluate the impact of TB treatment on HRQoL of new sm...

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Autores principales: Atif, Muhammad, Syed Sulaiman, Syed Azhar, Shafie, Asrul Akmal, Asif, Muhammad, Sarfraz, Muhammad Khan, Low, Heng Chin, Babar, Zaheer-Ud-Din
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925792/
https://www.ncbi.nlm.nih.gov/pubmed/24528499
http://dx.doi.org/10.1186/1477-7525-12-19
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author Atif, Muhammad
Syed Sulaiman, Syed Azhar
Shafie, Asrul Akmal
Asif, Muhammad
Sarfraz, Muhammad Khan
Low, Heng Chin
Babar, Zaheer-Ud-Din
author_facet Atif, Muhammad
Syed Sulaiman, Syed Azhar
Shafie, Asrul Akmal
Asif, Muhammad
Sarfraz, Muhammad Khan
Low, Heng Chin
Babar, Zaheer-Ud-Din
author_sort Atif, Muhammad
collection PubMed
description BACKGROUND: At present, much of the attention within tuberculosis (TB) management is spent on microbiological cure, and its impact on health-related quality of life (HRQoL) is either undervalued or seldom considered. The aim of this study was to evaluate the impact of TB treatment on HRQoL of new smear positive pulmonary tuberculosis (PTB) patients. Moreover, we also aimed to determine whether the selected socio-demographic and clinical variables were predictive of variability in the HRQoL scores over time. METHODS: This was a prospective follow-up of new smear positive PTB patients who were diagnosed at the chest clinic of Penang General Hospital between March 2010 and February 2011. All eligible patients (i.e., a new case of smear positive PTB, literate and aged 18 years or above) were asked to self-complete the SF-36v2 questionnaire at the start of their treatment, and then subsequently after the intensive phase and at the end of the treatment. A score on a health domain or component summary measure that was less than 47 norm-based scoring (NBS) point was considered indicative of impaired function within that health domain or dimension. Likewise, an individual having mental component summary (MCS) score ≤ 42 NBS point was considered to be at the risk of depression. Repeated measures ANOVA test was performed to examine how the summary scores varied over time, and to determine whether independent variables were predictive of variability in the physical component summary (PCS) and MCS scores over time. RESULTS: A total of 216 patients completed the SF-36v2 questionnaire at the start of their treatment. Out of these, 177 and 153 completed the questionnaire at the second and third follow-ups, respectively. The mean PCS scores at the start of the treatment, after the intensive phase and at the end of treatment were 41.9 (SD 5.1), 45.8 (SD 4.8) and 46.0 (SD 6.9), respectively. Similarly, the mean MCS scores at the start of the treatment, after the intensive phase and at the end of the treatment were 39.9 (SD 7.3), 45.0 (SD 6.8) and 46.8 (SD 7.8), respectively. More than 23% of the patients were at the risk of depression at the end of their TB treatment. Patient’s age and being a smoker were predictive of differences in the PCS scores. Similarly, monthly income, being a smoker and TB-related symptoms at the start of the treatment were predictive of differences in the MCS scores. CONCLUSION: Although HRQoL improved with the treatment, the scores on component summary measures showed compromised physical and mental health among study patients even at the end of their TB treatment.
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spelling pubmed-39257922014-02-18 Impact of tuberculosis treatment on health-related quality of life of pulmonary tuberculosis patients: a follow-up study Atif, Muhammad Syed Sulaiman, Syed Azhar Shafie, Asrul Akmal Asif, Muhammad Sarfraz, Muhammad Khan Low, Heng Chin Babar, Zaheer-Ud-Din Health Qual Life Outcomes Research BACKGROUND: At present, much of the attention within tuberculosis (TB) management is spent on microbiological cure, and its impact on health-related quality of life (HRQoL) is either undervalued or seldom considered. The aim of this study was to evaluate the impact of TB treatment on HRQoL of new smear positive pulmonary tuberculosis (PTB) patients. Moreover, we also aimed to determine whether the selected socio-demographic and clinical variables were predictive of variability in the HRQoL scores over time. METHODS: This was a prospective follow-up of new smear positive PTB patients who were diagnosed at the chest clinic of Penang General Hospital between March 2010 and February 2011. All eligible patients (i.e., a new case of smear positive PTB, literate and aged 18 years or above) were asked to self-complete the SF-36v2 questionnaire at the start of their treatment, and then subsequently after the intensive phase and at the end of the treatment. A score on a health domain or component summary measure that was less than 47 norm-based scoring (NBS) point was considered indicative of impaired function within that health domain or dimension. Likewise, an individual having mental component summary (MCS) score ≤ 42 NBS point was considered to be at the risk of depression. Repeated measures ANOVA test was performed to examine how the summary scores varied over time, and to determine whether independent variables were predictive of variability in the physical component summary (PCS) and MCS scores over time. RESULTS: A total of 216 patients completed the SF-36v2 questionnaire at the start of their treatment. Out of these, 177 and 153 completed the questionnaire at the second and third follow-ups, respectively. The mean PCS scores at the start of the treatment, after the intensive phase and at the end of treatment were 41.9 (SD 5.1), 45.8 (SD 4.8) and 46.0 (SD 6.9), respectively. Similarly, the mean MCS scores at the start of the treatment, after the intensive phase and at the end of the treatment were 39.9 (SD 7.3), 45.0 (SD 6.8) and 46.8 (SD 7.8), respectively. More than 23% of the patients were at the risk of depression at the end of their TB treatment. Patient’s age and being a smoker were predictive of differences in the PCS scores. Similarly, monthly income, being a smoker and TB-related symptoms at the start of the treatment were predictive of differences in the MCS scores. CONCLUSION: Although HRQoL improved with the treatment, the scores on component summary measures showed compromised physical and mental health among study patients even at the end of their TB treatment. BioMed Central 2014-02-14 /pmc/articles/PMC3925792/ /pubmed/24528499 http://dx.doi.org/10.1186/1477-7525-12-19 Text en Copyright © 2014 Atif et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Atif, Muhammad
Syed Sulaiman, Syed Azhar
Shafie, Asrul Akmal
Asif, Muhammad
Sarfraz, Muhammad Khan
Low, Heng Chin
Babar, Zaheer-Ud-Din
Impact of tuberculosis treatment on health-related quality of life of pulmonary tuberculosis patients: a follow-up study
title Impact of tuberculosis treatment on health-related quality of life of pulmonary tuberculosis patients: a follow-up study
title_full Impact of tuberculosis treatment on health-related quality of life of pulmonary tuberculosis patients: a follow-up study
title_fullStr Impact of tuberculosis treatment on health-related quality of life of pulmonary tuberculosis patients: a follow-up study
title_full_unstemmed Impact of tuberculosis treatment on health-related quality of life of pulmonary tuberculosis patients: a follow-up study
title_short Impact of tuberculosis treatment on health-related quality of life of pulmonary tuberculosis patients: a follow-up study
title_sort impact of tuberculosis treatment on health-related quality of life of pulmonary tuberculosis patients: a follow-up study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925792/
https://www.ncbi.nlm.nih.gov/pubmed/24528499
http://dx.doi.org/10.1186/1477-7525-12-19
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