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Changing glucocorticoid action: 11β-Hydroxysteroid dehydrogenase type 1 in acute and chronic inflammation

Since the discovery of cortisone in the 1940s and its early success in treatment of rheumatoid arthritis, glucocorticoids have remained the mainstay of anti-inflammatory therapies. However, cortisone itself is intrinsically inert. To be effective, it requires conversion to cortisol, the active gluco...

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Detalles Bibliográficos
Autores principales:	Chapman, Karen E., Coutinho, Agnes E., Zhang, Zhenguang, Kipari, Tiina, Savill, John S., Seckl, Jonathan R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Pergamon 2013
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925798/ https://www.ncbi.nlm.nih.gov/pubmed/23435016 http://dx.doi.org/10.1016/j.jsbmb.2013.02.002

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