Molecular mechanisms of template-independent RNA polymerization by tRNA nucleotidyltransferases

The universal 3′-terminal CCA sequence of tRNA is built and/or synthesized by the CCA-adding enzyme, CTP:(ATP) tRNA nucleotidyltransferase. This RNA polymerase has no nucleic acid template, but faithfully synthesizes the defined CCA sequence on the 3′-terminus of tRNA at one time, using CTP and ATP...

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Detalles Bibliográficos
Autores principales: Tomita, Kozo, Yamashita, Seisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925840/
https://www.ncbi.nlm.nih.gov/pubmed/24596576
http://dx.doi.org/10.3389/fgene.2014.00036
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author Tomita, Kozo
Yamashita, Seisuke
author_facet Tomita, Kozo
Yamashita, Seisuke
author_sort Tomita, Kozo
collection PubMed
description The universal 3′-terminal CCA sequence of tRNA is built and/or synthesized by the CCA-adding enzyme, CTP:(ATP) tRNA nucleotidyltransferase. This RNA polymerase has no nucleic acid template, but faithfully synthesizes the defined CCA sequence on the 3′-terminus of tRNA at one time, using CTP and ATP as substrates. The mystery of CCA-addition without a nucleic acid template by unique RNA polymerases has long fascinated researchers in the field of RNA enzymology. In this review, the mechanisms of RNA polymerization by the remarkable CCA-adding enzyme and its related enzymes are presented, based on their structural features.
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spelling pubmed-39258402014-03-04 Molecular mechanisms of template-independent RNA polymerization by tRNA nucleotidyltransferases Tomita, Kozo Yamashita, Seisuke Front Genet Genetics The universal 3′-terminal CCA sequence of tRNA is built and/or synthesized by the CCA-adding enzyme, CTP:(ATP) tRNA nucleotidyltransferase. This RNA polymerase has no nucleic acid template, but faithfully synthesizes the defined CCA sequence on the 3′-terminus of tRNA at one time, using CTP and ATP as substrates. The mystery of CCA-addition without a nucleic acid template by unique RNA polymerases has long fascinated researchers in the field of RNA enzymology. In this review, the mechanisms of RNA polymerization by the remarkable CCA-adding enzyme and its related enzymes are presented, based on their structural features. Frontiers Media S.A. 2014-02-17 /pmc/articles/PMC3925840/ /pubmed/24596576 http://dx.doi.org/10.3389/fgene.2014.00036 Text en Copyright © 2014 Tomita and Yamashita. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Tomita, Kozo
Yamashita, Seisuke
Molecular mechanisms of template-independent RNA polymerization by tRNA nucleotidyltransferases
title Molecular mechanisms of template-independent RNA polymerization by tRNA nucleotidyltransferases
title_full Molecular mechanisms of template-independent RNA polymerization by tRNA nucleotidyltransferases
title_fullStr Molecular mechanisms of template-independent RNA polymerization by tRNA nucleotidyltransferases
title_full_unstemmed Molecular mechanisms of template-independent RNA polymerization by tRNA nucleotidyltransferases
title_short Molecular mechanisms of template-independent RNA polymerization by tRNA nucleotidyltransferases
title_sort molecular mechanisms of template-independent rna polymerization by trna nucleotidyltransferases
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925840/
https://www.ncbi.nlm.nih.gov/pubmed/24596576
http://dx.doi.org/10.3389/fgene.2014.00036
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