Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation

Despite its clinical importance in infection and autoimmunity, the activation mechanisms of the NLRP1b inflammasome remain enigmatic. Here we show that deletion of the inflammasome adaptor ASC in BALB/c mice and in C57BL/6 macrophages expressing a functional NLRP1b prevents anthrax lethal toxin (LeT...

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Detalles Bibliográficos
Autores principales: Van Opdenbosch, Nina, Gurung, Prajwal, Vande Walle, Lieselotte, Fossoul, Amelie, Kanneganti, Thirumala-Devi, Lamkanfi, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926011/
https://www.ncbi.nlm.nih.gov/pubmed/24492532
http://dx.doi.org/10.1038/ncomms4209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926011/
https://www.ncbi.nlm.nih.gov/pubmed/24492532
http://dx.doi.org/10.1038/ncomms4209

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