Leukocytoclastic Vasculitis as a Complication of Recombinant Granulocyte Colony-Stimulating Factor Therapy in a Heart Transplant Patient

Recombinant granulocyte colony-stimulating factor (rG-CSF) is a myeloid growth factor that is widely used in haematology to recover neutropenia secondary to myelosuppressive chemotherapy. Leukocytoclastic vasculitis is an acknowledged side effect of the above therapy. Its pathogenesis involves many...

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Autores principales: Ippoliti, Giovanbattista, Paulli, Marco, Lucioni, Marco, Lauriola, Marinella, D'Armini, Andrea Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926260/
https://www.ncbi.nlm.nih.gov/pubmed/24600524
http://dx.doi.org/10.1155/2014/160407
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author Ippoliti, Giovanbattista
Paulli, Marco
Lucioni, Marco
Lauriola, Marinella
D'Armini, Andrea Maria
author_facet Ippoliti, Giovanbattista
Paulli, Marco
Lucioni, Marco
Lauriola, Marinella
D'Armini, Andrea Maria
author_sort Ippoliti, Giovanbattista
collection PubMed
description Recombinant granulocyte colony-stimulating factor (rG-CSF) is a myeloid growth factor that is widely used in haematology to recover neutropenia secondary to myelosuppressive chemotherapy. Leukocytoclastic vasculitis is an acknowledged side effect of the above therapy. Its pathogenesis involves many mechanisms that collectively induce an increase in neutrophil function and a subsequent release of cytokines. Here, we report a case of leukocytoclastic vasculitis proven by skin biopsy, following the use of rG-CSF in a heart transplant patient with leukopenia secondary to immunosuppressive therapy.
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spelling pubmed-39262602014-03-05 Leukocytoclastic Vasculitis as a Complication of Recombinant Granulocyte Colony-Stimulating Factor Therapy in a Heart Transplant Patient Ippoliti, Giovanbattista Paulli, Marco Lucioni, Marco Lauriola, Marinella D'Armini, Andrea Maria Case Rep Transplant Case Report Recombinant granulocyte colony-stimulating factor (rG-CSF) is a myeloid growth factor that is widely used in haematology to recover neutropenia secondary to myelosuppressive chemotherapy. Leukocytoclastic vasculitis is an acknowledged side effect of the above therapy. Its pathogenesis involves many mechanisms that collectively induce an increase in neutrophil function and a subsequent release of cytokines. Here, we report a case of leukocytoclastic vasculitis proven by skin biopsy, following the use of rG-CSF in a heart transplant patient with leukopenia secondary to immunosuppressive therapy. Hindawi Publishing Corporation 2014 2014-01-30 /pmc/articles/PMC3926260/ /pubmed/24600524 http://dx.doi.org/10.1155/2014/160407 Text en Copyright © 2014 Giovanbattista Ippoliti et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Ippoliti, Giovanbattista
Paulli, Marco
Lucioni, Marco
Lauriola, Marinella
D'Armini, Andrea Maria
Leukocytoclastic Vasculitis as a Complication of Recombinant Granulocyte Colony-Stimulating Factor Therapy in a Heart Transplant Patient
title Leukocytoclastic Vasculitis as a Complication of Recombinant Granulocyte Colony-Stimulating Factor Therapy in a Heart Transplant Patient
title_full Leukocytoclastic Vasculitis as a Complication of Recombinant Granulocyte Colony-Stimulating Factor Therapy in a Heart Transplant Patient
title_fullStr Leukocytoclastic Vasculitis as a Complication of Recombinant Granulocyte Colony-Stimulating Factor Therapy in a Heart Transplant Patient
title_full_unstemmed Leukocytoclastic Vasculitis as a Complication of Recombinant Granulocyte Colony-Stimulating Factor Therapy in a Heart Transplant Patient
title_short Leukocytoclastic Vasculitis as a Complication of Recombinant Granulocyte Colony-Stimulating Factor Therapy in a Heart Transplant Patient
title_sort leukocytoclastic vasculitis as a complication of recombinant granulocyte colony-stimulating factor therapy in a heart transplant patient
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926260/
https://www.ncbi.nlm.nih.gov/pubmed/24600524
http://dx.doi.org/10.1155/2014/160407
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