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Sex Dependence of Cognitive Functions in Bipolar Disorder

The objective of the present study was to assess the performance of lithium treated euthymic bipolar patients in tests measuring spatial working memory (SWM), planning, and verbal fluency and to delineate the influence of gender on cognitive functioning. Fifty-nine euthymic bipolar patients, treated...

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Detalles Bibliográficos
Autores principales: Suwalska, Aleksandra, Łojko, Dorota
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926268/
https://www.ncbi.nlm.nih.gov/pubmed/24616627
http://dx.doi.org/10.1155/2014/418432
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author Suwalska, Aleksandra
Łojko, Dorota
author_facet Suwalska, Aleksandra
Łojko, Dorota
author_sort Suwalska, Aleksandra
collection PubMed
description The objective of the present study was to assess the performance of lithium treated euthymic bipolar patients in tests measuring spatial working memory (SWM), planning, and verbal fluency and to delineate the influence of gender on cognitive functioning. Fifty-nine euthymic bipolar patients, treated with lithium carbonate for at least 5 yr, were studied. Patients and controls underwent a neuropsychological assessment. Bipolar patients had significantly worse results than the healthy controls in the spatial memory and planning as well as verbal fluency tests. We detected a gender-related imbalance in the SWM results. Deficits in SWM were observed in male-only comparisons but not in female-only comparisons. The SWM scores were significantly poorer in male patients than in male controls. In female-only comparisons, female patients did not have significantly poorer SWM results in any category than their controls. Bipolar women scored worse in some other tests. The present study points to the different patterns of neuropsychological disturbances in female and male patients and suggests that sex-dependent differences should be taken into account in order to tailor the therapeutic intervention aimed at the improvement of cognitive functions.
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spelling pubmed-39262682014-03-10 Sex Dependence of Cognitive Functions in Bipolar Disorder Suwalska, Aleksandra Łojko, Dorota ScientificWorldJournal Research Article The objective of the present study was to assess the performance of lithium treated euthymic bipolar patients in tests measuring spatial working memory (SWM), planning, and verbal fluency and to delineate the influence of gender on cognitive functioning. Fifty-nine euthymic bipolar patients, treated with lithium carbonate for at least 5 yr, were studied. Patients and controls underwent a neuropsychological assessment. Bipolar patients had significantly worse results than the healthy controls in the spatial memory and planning as well as verbal fluency tests. We detected a gender-related imbalance in the SWM results. Deficits in SWM were observed in male-only comparisons but not in female-only comparisons. The SWM scores were significantly poorer in male patients than in male controls. In female-only comparisons, female patients did not have significantly poorer SWM results in any category than their controls. Bipolar women scored worse in some other tests. The present study points to the different patterns of neuropsychological disturbances in female and male patients and suggests that sex-dependent differences should be taken into account in order to tailor the therapeutic intervention aimed at the improvement of cognitive functions. Hindawi Publishing Corporation 2014-01-29 /pmc/articles/PMC3926268/ /pubmed/24616627 http://dx.doi.org/10.1155/2014/418432 Text en Copyright © 2014 A. Suwalska and D. Łojko. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Suwalska, Aleksandra
Łojko, Dorota
Sex Dependence of Cognitive Functions in Bipolar Disorder
title Sex Dependence of Cognitive Functions in Bipolar Disorder
title_full Sex Dependence of Cognitive Functions in Bipolar Disorder
title_fullStr Sex Dependence of Cognitive Functions in Bipolar Disorder
title_full_unstemmed Sex Dependence of Cognitive Functions in Bipolar Disorder
title_short Sex Dependence of Cognitive Functions in Bipolar Disorder
title_sort sex dependence of cognitive functions in bipolar disorder
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926268/
https://www.ncbi.nlm.nih.gov/pubmed/24616627
http://dx.doi.org/10.1155/2014/418432
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