Cargando…

Specific CT 3D rendering of the treatment zone after Irreversible Electroporation (IRE) in a pig liver model: the “Chebyshev Center Concept” to define the maximum treatable tumor size

BACKGROUND: Size and shape of the treatment zone after Irreversible electroporation (IRE) can be difficult to depict due to the use of multiple applicators with complex spatial configuration. Exact geometrical definition of the treatment zone, however, is mandatory for acute treatment control since...

Descripción completa

Detalles Bibliográficos
Autores principales: Vollherbst, Dominik, Fritz, Stefan, Zelzer, Sascha, Wachter, Miguel F, Wolf, Maya B, Stampfl, Ulrike, Gnutzmann, Daniel, Bellemann, Nadine, Schmitz, Anne, Knapp, Jürgen, Pereira, Philippe L, Kauczor, Hans U, Werner, Jens, Radeleff, Boris A, Sommer, Christof M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926307/
https://www.ncbi.nlm.nih.gov/pubmed/24410997
http://dx.doi.org/10.1186/1471-2342-14-2
_version_ 1782303956718845952
author Vollherbst, Dominik
Fritz, Stefan
Zelzer, Sascha
Wachter, Miguel F
Wolf, Maya B
Stampfl, Ulrike
Gnutzmann, Daniel
Bellemann, Nadine
Schmitz, Anne
Knapp, Jürgen
Pereira, Philippe L
Kauczor, Hans U
Werner, Jens
Radeleff, Boris A
Sommer, Christof M
author_facet Vollherbst, Dominik
Fritz, Stefan
Zelzer, Sascha
Wachter, Miguel F
Wolf, Maya B
Stampfl, Ulrike
Gnutzmann, Daniel
Bellemann, Nadine
Schmitz, Anne
Knapp, Jürgen
Pereira, Philippe L
Kauczor, Hans U
Werner, Jens
Radeleff, Boris A
Sommer, Christof M
author_sort Vollherbst, Dominik
collection PubMed
description BACKGROUND: Size and shape of the treatment zone after Irreversible electroporation (IRE) can be difficult to depict due to the use of multiple applicators with complex spatial configuration. Exact geometrical definition of the treatment zone, however, is mandatory for acute treatment control since incomplete tumor coverage results in limited oncological outcome. In this study, the “Chebyshev Center Concept” was introduced for CT 3d rendering to assess size and position of the maximum treatable tumor at a specific safety margin. METHODS: In seven pig livers, three different IRE protocols were applied to create treatment zones of different size and shape: Protocol 1 (n = 5 IREs), Protocol 2 (n = 5 IREs), and Protocol 3 (n = 5 IREs). Contrast-enhanced CT was used to assess the treatment zones. Technique A consisted of a semi-automated software prototype for CT 3d rendering with the “Chebyshev Center Concept” implemented (the “Chebyshev Center” is the center of the largest inscribed sphere within the treatment zone) with automated definition of parameters for size, shape and position. Technique B consisted of standard CT 3d analysis with manual definition of the same parameters but position. RESULTS: For Protocol 1 and 2, short diameter of the treatment zone and diameter of the largest inscribed sphere within the treatment zone were not significantly different between Technique A and B. For Protocol 3, short diameter of the treatment zone and diameter of the largest inscribed sphere within the treatment zone were significantly smaller for Technique A compared with Technique B (41.1 ± 13.1 mm versus 53.8 ± 1.1 mm and 39.0 ± 8.4 mm versus 53.8 ± 1.1 mm; p < 0.05 and p < 0.01). For Protocol 1, 2 and 3, sphericity of the treatment zone was significantly larger for Technique A compared with B. CONCLUSIONS: Regarding size and shape of the treatment zone after IRE, CT 3d rendering with the “Chebyshev Center Concept” implemented provides significantly different results compared with standard CT 3d analysis. Since the latter overestimates the size of the treatment zone, the “Chebyshev Center Concept” could be used for a more objective acute treatment control.
format Online
Article
Text
id pubmed-3926307
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-39263072014-02-18 Specific CT 3D rendering of the treatment zone after Irreversible Electroporation (IRE) in a pig liver model: the “Chebyshev Center Concept” to define the maximum treatable tumor size Vollherbst, Dominik Fritz, Stefan Zelzer, Sascha Wachter, Miguel F Wolf, Maya B Stampfl, Ulrike Gnutzmann, Daniel Bellemann, Nadine Schmitz, Anne Knapp, Jürgen Pereira, Philippe L Kauczor, Hans U Werner, Jens Radeleff, Boris A Sommer, Christof M BMC Med Imaging Research Article BACKGROUND: Size and shape of the treatment zone after Irreversible electroporation (IRE) can be difficult to depict due to the use of multiple applicators with complex spatial configuration. Exact geometrical definition of the treatment zone, however, is mandatory for acute treatment control since incomplete tumor coverage results in limited oncological outcome. In this study, the “Chebyshev Center Concept” was introduced for CT 3d rendering to assess size and position of the maximum treatable tumor at a specific safety margin. METHODS: In seven pig livers, three different IRE protocols were applied to create treatment zones of different size and shape: Protocol 1 (n = 5 IREs), Protocol 2 (n = 5 IREs), and Protocol 3 (n = 5 IREs). Contrast-enhanced CT was used to assess the treatment zones. Technique A consisted of a semi-automated software prototype for CT 3d rendering with the “Chebyshev Center Concept” implemented (the “Chebyshev Center” is the center of the largest inscribed sphere within the treatment zone) with automated definition of parameters for size, shape and position. Technique B consisted of standard CT 3d analysis with manual definition of the same parameters but position. RESULTS: For Protocol 1 and 2, short diameter of the treatment zone and diameter of the largest inscribed sphere within the treatment zone were not significantly different between Technique A and B. For Protocol 3, short diameter of the treatment zone and diameter of the largest inscribed sphere within the treatment zone were significantly smaller for Technique A compared with Technique B (41.1 ± 13.1 mm versus 53.8 ± 1.1 mm and 39.0 ± 8.4 mm versus 53.8 ± 1.1 mm; p < 0.05 and p < 0.01). For Protocol 1, 2 and 3, sphericity of the treatment zone was significantly larger for Technique A compared with B. CONCLUSIONS: Regarding size and shape of the treatment zone after IRE, CT 3d rendering with the “Chebyshev Center Concept” implemented provides significantly different results compared with standard CT 3d analysis. Since the latter overestimates the size of the treatment zone, the “Chebyshev Center Concept” could be used for a more objective acute treatment control. BioMed Central 2014-01-10 /pmc/articles/PMC3926307/ /pubmed/24410997 http://dx.doi.org/10.1186/1471-2342-14-2 Text en Copyright © 2014 Vollherbst et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Vollherbst, Dominik
Fritz, Stefan
Zelzer, Sascha
Wachter, Miguel F
Wolf, Maya B
Stampfl, Ulrike
Gnutzmann, Daniel
Bellemann, Nadine
Schmitz, Anne
Knapp, Jürgen
Pereira, Philippe L
Kauczor, Hans U
Werner, Jens
Radeleff, Boris A
Sommer, Christof M
Specific CT 3D rendering of the treatment zone after Irreversible Electroporation (IRE) in a pig liver model: the “Chebyshev Center Concept” to define the maximum treatable tumor size
title Specific CT 3D rendering of the treatment zone after Irreversible Electroporation (IRE) in a pig liver model: the “Chebyshev Center Concept” to define the maximum treatable tumor size
title_full Specific CT 3D rendering of the treatment zone after Irreversible Electroporation (IRE) in a pig liver model: the “Chebyshev Center Concept” to define the maximum treatable tumor size
title_fullStr Specific CT 3D rendering of the treatment zone after Irreversible Electroporation (IRE) in a pig liver model: the “Chebyshev Center Concept” to define the maximum treatable tumor size
title_full_unstemmed Specific CT 3D rendering of the treatment zone after Irreversible Electroporation (IRE) in a pig liver model: the “Chebyshev Center Concept” to define the maximum treatable tumor size
title_short Specific CT 3D rendering of the treatment zone after Irreversible Electroporation (IRE) in a pig liver model: the “Chebyshev Center Concept” to define the maximum treatable tumor size
title_sort specific ct 3d rendering of the treatment zone after irreversible electroporation (ire) in a pig liver model: the “chebyshev center concept” to define the maximum treatable tumor size
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926307/
https://www.ncbi.nlm.nih.gov/pubmed/24410997
http://dx.doi.org/10.1186/1471-2342-14-2
work_keys_str_mv AT vollherbstdominik specificct3drenderingofthetreatmentzoneafterirreversibleelectroporationireinapiglivermodelthechebyshevcenterconcepttodefinethemaximumtreatabletumorsize
AT fritzstefan specificct3drenderingofthetreatmentzoneafterirreversibleelectroporationireinapiglivermodelthechebyshevcenterconcepttodefinethemaximumtreatabletumorsize
AT zelzersascha specificct3drenderingofthetreatmentzoneafterirreversibleelectroporationireinapiglivermodelthechebyshevcenterconcepttodefinethemaximumtreatabletumorsize
AT wachtermiguelf specificct3drenderingofthetreatmentzoneafterirreversibleelectroporationireinapiglivermodelthechebyshevcenterconcepttodefinethemaximumtreatabletumorsize
AT wolfmayab specificct3drenderingofthetreatmentzoneafterirreversibleelectroporationireinapiglivermodelthechebyshevcenterconcepttodefinethemaximumtreatabletumorsize
AT stampflulrike specificct3drenderingofthetreatmentzoneafterirreversibleelectroporationireinapiglivermodelthechebyshevcenterconcepttodefinethemaximumtreatabletumorsize
AT gnutzmanndaniel specificct3drenderingofthetreatmentzoneafterirreversibleelectroporationireinapiglivermodelthechebyshevcenterconcepttodefinethemaximumtreatabletumorsize
AT bellemannnadine specificct3drenderingofthetreatmentzoneafterirreversibleelectroporationireinapiglivermodelthechebyshevcenterconcepttodefinethemaximumtreatabletumorsize
AT schmitzanne specificct3drenderingofthetreatmentzoneafterirreversibleelectroporationireinapiglivermodelthechebyshevcenterconcepttodefinethemaximumtreatabletumorsize
AT knappjurgen specificct3drenderingofthetreatmentzoneafterirreversibleelectroporationireinapiglivermodelthechebyshevcenterconcepttodefinethemaximumtreatabletumorsize
AT pereiraphilippel specificct3drenderingofthetreatmentzoneafterirreversibleelectroporationireinapiglivermodelthechebyshevcenterconcepttodefinethemaximumtreatabletumorsize
AT kauczorhansu specificct3drenderingofthetreatmentzoneafterirreversibleelectroporationireinapiglivermodelthechebyshevcenterconcepttodefinethemaximumtreatabletumorsize
AT wernerjens specificct3drenderingofthetreatmentzoneafterirreversibleelectroporationireinapiglivermodelthechebyshevcenterconcepttodefinethemaximumtreatabletumorsize
AT radeleffborisa specificct3drenderingofthetreatmentzoneafterirreversibleelectroporationireinapiglivermodelthechebyshevcenterconcepttodefinethemaximumtreatabletumorsize
AT sommerchristofm specificct3drenderingofthetreatmentzoneafterirreversibleelectroporationireinapiglivermodelthechebyshevcenterconcepttodefinethemaximumtreatabletumorsize