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Investigation of Sesamol on Myeloperoxidase and Colon Morphology in Acetic Acid-Induced Inflammatory Bowel Disorder in Albino Rats

Background. Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of gastrointestinal tract of immune, genetic, and environmental origin. In the present study, we examined the effects of sesamol (SES), which is the active constituent of sesame oil in the acetic acid (AA) induced model...

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Autores principales: Kondamudi, Phani Krishna, Kovelamudi, Hemalatha, Mathew, Geetha, Nayak, Pawan G., Rao, Mallikarjuna C., Shenoy, Rekha R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926374/
https://www.ncbi.nlm.nih.gov/pubmed/24616646
http://dx.doi.org/10.1155/2014/802701
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author Kondamudi, Phani Krishna
Kovelamudi, Hemalatha
Mathew, Geetha
Nayak, Pawan G.
Rao, Mallikarjuna C.
Shenoy, Rekha R.
author_facet Kondamudi, Phani Krishna
Kovelamudi, Hemalatha
Mathew, Geetha
Nayak, Pawan G.
Rao, Mallikarjuna C.
Shenoy, Rekha R.
author_sort Kondamudi, Phani Krishna
collection PubMed
description Background. Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of gastrointestinal tract of immune, genetic, and environmental origin. In the present study, we examined the effects of sesamol (SES), which is the active constituent of sesame oil in the acetic acid (AA) induced model for IBD in rats. Methods. The groups were divided into normal control, AA control, SES, and sulfasalazine (SS). On day 7, the rats were killed, colon was removed, and the macroscopic, biochemical, and histopathological evaluations were performed. Results. The levels of MPO, TBARS, and tissue nitrite increased significantly (P < 0.05) in the AA group whereas they reduced significantly in the SES and SS treated groups. Serum nitrite levels were found to be insignificant between the different groups. Conclusions. The mucosal protective effects of sesamol in IBD are due to its potential to reduce the myeloperoxidase and nitrite content.
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spelling pubmed-39263742014-03-10 Investigation of Sesamol on Myeloperoxidase and Colon Morphology in Acetic Acid-Induced Inflammatory Bowel Disorder in Albino Rats Kondamudi, Phani Krishna Kovelamudi, Hemalatha Mathew, Geetha Nayak, Pawan G. Rao, Mallikarjuna C. Shenoy, Rekha R. ScientificWorldJournal Research Article Background. Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of gastrointestinal tract of immune, genetic, and environmental origin. In the present study, we examined the effects of sesamol (SES), which is the active constituent of sesame oil in the acetic acid (AA) induced model for IBD in rats. Methods. The groups were divided into normal control, AA control, SES, and sulfasalazine (SS). On day 7, the rats were killed, colon was removed, and the macroscopic, biochemical, and histopathological evaluations were performed. Results. The levels of MPO, TBARS, and tissue nitrite increased significantly (P < 0.05) in the AA group whereas they reduced significantly in the SES and SS treated groups. Serum nitrite levels were found to be insignificant between the different groups. Conclusions. The mucosal protective effects of sesamol in IBD are due to its potential to reduce the myeloperoxidase and nitrite content. Hindawi Publishing Corporation 2014-01-30 /pmc/articles/PMC3926374/ /pubmed/24616646 http://dx.doi.org/10.1155/2014/802701 Text en Copyright © 2014 Phani Krishna Kondamudi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kondamudi, Phani Krishna
Kovelamudi, Hemalatha
Mathew, Geetha
Nayak, Pawan G.
Rao, Mallikarjuna C.
Shenoy, Rekha R.
Investigation of Sesamol on Myeloperoxidase and Colon Morphology in Acetic Acid-Induced Inflammatory Bowel Disorder in Albino Rats
title Investigation of Sesamol on Myeloperoxidase and Colon Morphology in Acetic Acid-Induced Inflammatory Bowel Disorder in Albino Rats
title_full Investigation of Sesamol on Myeloperoxidase and Colon Morphology in Acetic Acid-Induced Inflammatory Bowel Disorder in Albino Rats
title_fullStr Investigation of Sesamol on Myeloperoxidase and Colon Morphology in Acetic Acid-Induced Inflammatory Bowel Disorder in Albino Rats
title_full_unstemmed Investigation of Sesamol on Myeloperoxidase and Colon Morphology in Acetic Acid-Induced Inflammatory Bowel Disorder in Albino Rats
title_short Investigation of Sesamol on Myeloperoxidase and Colon Morphology in Acetic Acid-Induced Inflammatory Bowel Disorder in Albino Rats
title_sort investigation of sesamol on myeloperoxidase and colon morphology in acetic acid-induced inflammatory bowel disorder in albino rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926374/
https://www.ncbi.nlm.nih.gov/pubmed/24616646
http://dx.doi.org/10.1155/2014/802701
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