Nucleoside Sensing

A rigid molecular clip comprising bisphosphonate binding sites and aromatic sidewalls forming an electron-rich cavity is able to distinguish between nucleosides and nucleotides in aqueous solution. Neutral nucleosides as well as antibiotics derived thereof are drawn into the unpolar interior of the...

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Detalles Bibliográficos
Autores principales: Fokkens, Michael, Klärner, Frank-Gerrit, Schrader, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2006
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926528/
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author Fokkens, Michael
Klärner, Frank-Gerrit
Schrader, Thomas
author_facet Fokkens, Michael
Klärner, Frank-Gerrit
Schrader, Thomas
author_sort Fokkens, Michael
collection PubMed
description A rigid molecular clip comprising bisphosphonate binding sites and aromatic sidewalls forming an electron-rich cavity is able to distinguish between nucleosides and nucleotides in aqueous solution. Neutral nucleosides as well as antibiotics derived thereof are drawn into the unpolar interior of the cleft and lead to substantial upfield-shifts in the (1)H NMR spectrum. Nucleoside drugs can therefore be detected with high selectivity in the presence of their phosphorylated pendants or nucleic acids.
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spelling pubmed-39265282014-02-18 Nucleoside Sensing Fokkens, Michael Klärner, Frank-Gerrit Schrader, Thomas Sensors (Basel) Full Research Paper A rigid molecular clip comprising bisphosphonate binding sites and aromatic sidewalls forming an electron-rich cavity is able to distinguish between nucleosides and nucleotides in aqueous solution. Neutral nucleosides as well as antibiotics derived thereof are drawn into the unpolar interior of the cleft and lead to substantial upfield-shifts in the (1)H NMR spectrum. Nucleoside drugs can therefore be detected with high selectivity in the presence of their phosphorylated pendants or nucleic acids. Molecular Diversity Preservation International (MDPI) 2006-08-24 /pmc/articles/PMC3926528/ Text en 2006 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Full Research Paper
Fokkens, Michael
Klärner, Frank-Gerrit
Schrader, Thomas
Nucleoside Sensing
title Nucleoside Sensing
title_full Nucleoside Sensing
title_fullStr Nucleoside Sensing
title_full_unstemmed Nucleoside Sensing
title_short Nucleoside Sensing
title_sort nucleoside sensing
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926528/
work_keys_str_mv AT fokkensmichael nucleosidesensing
AT klarnerfrankgerrit nucleosidesensing
AT schraderthomas nucleosidesensing

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