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Induction of polyploidy by nuclear fusion mechanism upon decreased expression of the nuclear envelope protein LAP2β in the human osteosarcoma cell line U2OS

BACKGROUND: Polyploidy has been recognized for many years as an important hallmark of cancer cells. Polyploid cells can arise through cell fusion, endoreplication and abortive cell cycle. The inner nuclear membrane protein LAP2β plays key roles in nuclear envelope breakdown and reassembly during mit...

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Detalles Bibliográficos
Autores principales:	Ben-Shoshan, Shirley Oren, Simon, Amos J, Jacob-Hirsch, Jasmine, Shaklai, Sigal, Paz-Yaacov, Nurit, Amariglio, Ninette, Rechavi, Gideon, Trakhtenbrot, Luba
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926685/ https://www.ncbi.nlm.nih.gov/pubmed/24472424 http://dx.doi.org/10.1186/1755-8166-7-9

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