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Combinatorial antitumor effect of HDACs and the PI3K-Akt-mTOR pathway inhibition in a Pten deficient model of prostate cancer

Increased expression of histone deacetylases (HDACs) and activation of the PI3K-Akt-mTORC1 pathway are common aberrations in prostate cancer (PCa). For this reason, inhibition of such targets is an exciting avenue for the development of novel therapeutic strategies to treat patients with advanced PC...

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Detalles Bibliográficos
Autores principales:	Ellis, Leigh, Ku, ShengYu, Ramakrishnan, Swathi, Lasorsa, Elena, Azabdaftari, Gizzou, Godoy, Alejandro, Pili, Roberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2013
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926822/ https://www.ncbi.nlm.nih.gov/pubmed/24163230

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