Gefitinib resistance resulted from STAT3-mediated Akt activation in lung cancer cells

Hyperactivation of Epidermal Growth Factor Receptor (EGFR) tyrosine kinase is prevalent in human lung cancer and its inhibition by the tyrosine kinase inhibitors (TKIs), including gefitinib and erlotinib, initially controls tumor growth. However, most patients ultimately relapse due to the developme...

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Detalles Bibliográficos
Autores principales: Wu, Kai, Chang, Qingshan, Lu, Yongju, Qiu, Ping, Chen, Bailing, Thakur, Chitra, Sun, Jiaying, Li, Lingzhi, Kowluru, Anjaneyulu, Chen, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926838/
https://www.ncbi.nlm.nih.gov/pubmed/24280348

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926838/
https://www.ncbi.nlm.nih.gov/pubmed/24280348

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